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Comment
. 2024 Apr 9;57(4):834-836.
doi: 10.1016/j.immuni.2024.03.006.

Hostile bile limits anti-cancer immunity

Pavitha Parathan  1 , Lisa A Mielke  2
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Free article
Comment

Hostile bile limits anti-cancer immunity

Pavitha Parathan et al. Immunity. .
Free article

Abstract

Various microbial metabolites promote cell transformation. In this issue of Immunity, Cong et al. show that deoxycholic acid (DCA), a microbial metabolite of bile, promotes tumor growth by suppressing antitumor CD8+ T cell responses via dysregulation of calcium efflux.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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