Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2024 Apr 9;57(4):837-839.
doi: 10.1016/j.immuni.2024.03.011.

Depression: Monocytes on my mind

Gisela Paola Lazzarino  1 , David Engblom  2
Affiliations
Free article
Comment

Depression: Monocytes on my mind

Gisela Paola Lazzarino et al. Immunity. .
Free article

Abstract

Activation of the peripheral immune system contributes to stress-related neuropsychiatric symptoms. Recently in Nature, Cathomas et al. demonstrate that stress-induced social avoidance is mediated by monocyte-derived MMP8 that remodels the extracellular space of the nucleus accumbens.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Circulating myeloid-derived MMP8 in stress susceptibility and depression.
    Cathomas F, Lin HY, Chan KL, Li L, Parise LF, Alvarez J, Durand-de Cuttoli R, Aubry AV, Muhareb S, Desland F, Shimo Y, Ramakrishnan A, Estill M, Ferrer-Pérez C, Parise EM, Wilk CM, Kaster MP, Wang J, Sowa A, Janssen WG, Costi S, Rahman A, Fernandez N, Campbell M, Swirski FK, Nestler EJ, Shen L, Merad M, Murrough JW, Russo SJ. Cathomas F, et al. Nature. 2024 Feb;626(8001):1108-1115. doi: 10.1038/s41586-023-07015-2. Epub 2024 Feb 7. Nature. 2024. PMID: 38326622 Free PMC article.

References

Publication types