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Review
. 2024 Mar 27:15:1354806.
doi: 10.3389/fphar.2024.1354806. eCollection 2024.

Functional roles of circular RNAs in lung injury

Fei-Fei Gao #  1 , Dian-Qing Chen #  2 , Yue-Tong Jiang #  3 , Cui-Fei Han  3 , Bi-Yun Lin  4 , Zhan Yang  4 , Juan-Hua Quan  5 , Ying-Huan Xiong  4 , Xin-Tian Chen  5
Affiliations
Review

Functional roles of circular RNAs in lung injury

Fei-Fei Gao et al. Front Pharmacol. .

Abstract

Lung injury leads to respiratory dysfunction, low quality of life, and even life-threatening conditions. Circular RNAs (circRNAs) are endogenous RNAs produced by selective RNA splicing. Studies have reported their involvement in the progression of lung injury. Understanding the roles of circRNAs in lung injury may aid in elucidating the underlying mechanisms and provide new therapeutic targets. Thus, in this review, we aimed to summarize and discuss the characteristics and biological functions of circRNAs, and their roles in lung injury from existing research, to provide a theoretical basis for the use of circRNAs as a diagnostic and therapeutic target for lung injury.

Keywords: circRNA; fibrosis; inflammation; lung injury; macrophage; smoking.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
circRNAs participate in the lung injury. Lung injury can be caused by various etiologies, including infection, toxic substances inhalation, even some treatments maybe the contributing injury factors. circRNAs are involved in the pathological process of lung injury through different mechanisms.
FIGURE 2
FIGURE 2
circRNAs participate in infection-associated lung injury. The schematic diagram depicts the known role of circRNAs in infection-associated lung injury progression.
See this image and copyright information in PMC

References

    1. Aufiero S., Reckman Y. J., Pinto Y. M., Creemers E. E. (2019). Circular RNAs open a new chapter in cardiovascular biology. Nat. Rev. Cardiol. 16, 503–514. 10.1038/s41569-019-0185-2 - DOI - PubMed
    1. Bai J., Deng J., Han Z., Cui Y., He R., Gu Y., et al. (2021). CircRNA_0026344 via exosomal miR-21 regulation of Smad7 is involved in aberrant cross-talk of epithelium-fibroblasts during cigarette smoke-induced pulmonary fibrosis. Toxicol. Lett. 347, 58–66. 10.1016/j.toxlet.2021.04.017 - DOI - PubMed
    1. Bao X., Zhang Q., Liu N., Zhuang S., Li Z., Meng Q., et al. (2019). Characteristics of circular RNA expression of pulmonary macrophages in mice with sepsis-induced acute lung injury. J. Cell. Mol. Med. 23, 7111–7115. 10.1111/jcmm.14577 - DOI - PMC - PubMed
    1. Bellido-Reyes Y. A., Akamatsu H., Kojima K., Arai H., Tanaka H., Sunamori M. (2006). Cytosolic phospholipase A2 inhibition attenuates ischemia-reperfusion injury in an isolated rat lung model. Transplantation 81, 1700–1707. 10.1097/01.tp.0000226065.82066.21 - DOI - PubMed
    1. Black M., Milewski D., Le T., Ren X., Xu Y., Kalinichenko V. V., et al. (2018). FOXF1 inhibits pulmonary fibrosis by preventing CDH2-CDH11 cadherin switch in myofibroblasts. Cell Rep. 23, 442–458. 10.1016/j.celrep.2018.03.067 - DOI - PMC - PubMed

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