Longer sleep duration in Alzheimer's disease progression: a compensatory response?

Peng Li^{1

2

3}, Lei Gao^{1

2

3}, Brendan P Lucey^{4

5}, Yo-El S Ju^{4

5

6}, Erik S Musiek^{4

5

6}, Kun Hu^{1

2

3}

Affiliations

¹ Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
² Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
³ Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁴ Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.
⁵ Center on Biological Rhythms and Sleep (COBRAS), Washington University School of Medicine, St Louis, MO, USA.
⁶ Department of Anesthesiology, Washington University, St Louis, MO, USA.

Editorial

Peng Li et al. Sleep. 2024.

. 2024 Jun 13;47(6):zsae093.

doi: 10.1093/sleep/zsae093.

Peng Li^{1

2

3}, Lei Gao^{1

2

3}, Brendan P Lucey^{4

5}, Yo-El S Ju^{4

5

6}, Erik S Musiek^{4

5

6}, Kun Hu^{1

2

3}

¹ Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
² Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
³ Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁴ Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.
⁵ Center on Biological Rhythms and Sleep (COBRAS), Washington University School of Medicine, St Louis, MO, USA.
⁶ Department of Anesthesiology, Washington University, St Louis, MO, USA.

No abstract available

Comment on

Longer sleep duration and neuroinflammation in at-risk elderly with a parental history of Alzheimer's disease.
Baril AA, Picard C, Labonté A, Sanchez E, Duclos C, Mohammediyan B, Breitner JCS, Villeneuve S, Poirier J; PREVENT-AD Research Group. Baril AA, et al. Sleep. 2024 Jun 13;47(6):zsae081. doi: 10.1093/sleep/zsae081. Sleep. 2024. PMID: 38526098 Free PMC article.

1. Ju YES, Lucey BP, Holtzman DM.. Sleep and Alzheimer disease pathology--a bidirectional relationship. Nat Rev Neurol. 2014;10(2):115–119. doi: 10.1038/nrneurol.2013.269 - DOI - PMC - PubMed
1. Fan L, Xu W, Cai Y, Hu Y, Wu C.. Sleep Duration and the risk of dementia: a systematic review and meta-analysis of prospective cohort studies. J Am Med Dir Assoc. 2019;20(12):1480–1487.e5. doi: 10.1016/j.jamda.2019.06.009 - DOI - PubMed
1. Lucey BP. It’s complicated: the relationship between sleep and Alzheimer’s disease in humans. Neurobiol Dis. 2020;144:105031. doi: 10.1016/j.nbd.2020.105031 - DOI - PMC - PubMed
1. Lucey BP, Wisch J, Boerwinkle AH, et al.. Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer’s disease. Brain. 2021;144(9):2852–2862. doi: 10.1093/brain/awab272 - DOI - PMC - PubMed
1. Besedovsky L, Lange T, Haack M.. The sleep-immune crosstalk in health and disease. Physiol Rev. 2019;99(3):1325–1380. doi: 10.1152/physrev.00010.2018 - DOI - PMC - PubMed