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Review
. 2024 Apr;52(4):3000605241242582.
doi: 10.1177/03000605241242582.

Temporomandibular disorders among Ehlers-Danlos syndromes: a narrative review

Ole Oelerich  1 , Linda Daume  2 , Negin Yekkalam  3 , Marcel Hanisch  2 , Max C Menne  1   4
Affiliations
Review

Temporomandibular disorders among Ehlers-Danlos syndromes: a narrative review

Ole Oelerich et al. J Int Med Res. 2024 Apr.

Abstract

This narrative review aims to demonstrate and summarize the complex relationship between Ehlers-Danlos syndromes (EDS) and temporomandibular disorders (TMD) by reviewing the results of observational studies and case reports. EDS are a set of hereditary connective tissue disorders, where generalized joint hypermobility (GJH), especially in the hypermobile subtype (hEDS), is a key symptom. Mutations have been identified in genes that impact the production or assembly of collagen for all subtypes except hEDS. While the correlation between GJH and TMD has been analysed in various studies, fewer studies have examined TMD in patients with EDS, with most showing an increased prevalence of TMD. In case-control studies, an elevated prevalence of myalgia, arthralgia and disc-related disorders was found in individuals with EDS. Various therapeutic interventions have been reported within the literature in the form of case reports and observational studies, but there are no long-term clinical trials with results on the efficacy of different therapeutic approaches to date. This review demonstrates the high prevalence of different TMDs in different subtypes of EDS, but also shows that little is known about the success of treatment thus far. Further clinical research is necessary to provide adequate guidance on targeted treatment.

Keywords: Ehlers-Danlos syndromes; Temporomandibular disorders; narrative review; rare diseases.

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Conflict of interest statement

Declaration of conflicting interestThe authors declare that there are no conflicts of interest.

Figures

Figure 1.
Figure 1.
Taxonomic classification of temporomandibular disorders (TMD).
Figure 2.
Figure 2.
Overview of performed treatments for temporomandibular disorders (TMD) in patients with Ehlers-Danlos syndromes (EDS).,–,,
See this image and copyright information in PMC

References

    1. Malfait F, Francomano C, Byers P, et al. The 2017 international classification of the Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet 2017; 175: 8–26. - PubMed
    1. Vanakker O, Callewaert B, Malfait F, et al. The Genetics of Soft Connective Tissue Disorders. Annu Rev Genomics Hum Genet 2015; 16: 229–255. - PubMed
    1. Castori M, Tinkle B, Levy H, et al. A framework for the classification of joint hypermobility and related conditions. Am J Med Genet C Semin Med Genet 2017; 175: 148–157. - PubMed
    1. De Coster PJ, Van den Berghe LI, Martens LC. Generalized Joint Hypermobility and Temporomandibular Disorders: Inherited Connective Tissue Disease as a Model with Maximum Expression. J Orofac Pain 2005; 19: 47–57. - PubMed
    1. Syx D, De Wandele I, Rombaut L, et al. Hypermobility, the Ehlers-Danlos syndromes and chronic pain. Clin Exp Rheumatol 2017; 35: 116–122. - PubMed

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