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Review
. 2024 Jul;71(7):e31000.
doi: 10.1002/pbc.31000. Epub 2024 Apr 11.

Anaplasia in Wilms tumor: A critical review

Gordan M Vujanić  1   2 , William Mifsud  1   2
Affiliations
Review

Anaplasia in Wilms tumor: A critical review

Gordan M Vujanić et al. Pediatr Blood Cancer. 2024 Jul.

Abstract

Anaplasia in Wilms tumor is recognized as the most important prognostically unfavorable histological feature. It is subtyped as focal anaplastic Wilms tumor (FAWT) and diffuse anaplastic Wilms tumor (DAWT). Outcomes of patients with DAWT remain poor in patients with stage III and IV tumors. Important issues relevant to anaplasia in Wilms tumor, including prevalence, treatment, outcomes, biomarkers, anaplasia, and chemotherapy, and the concept of tumor aggressiveness, are reviewed and discussed here. We also consider the differences in clinical approaches to anaplasia in Wilms tumor between the two major renal tumor clinical research groups: the International Society of Paediatric Oncology (SIOP) Renal Tumour Study Group and the Children's Oncology Group (COG) Renal Tumor Group. We emphasize the importance and implications of recognizing FAWT and DAWT as separate clinico-pathological entities.

Keywords: COG; SIOP; Wilms tumor; anaplasia; chemotherapy resistance; diffuse anaplasia; focal anaplasia; tumor aggressiveness.

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References

REFERENCES

    1. Beckwith JB, Palmer NF. Histopathology and prognosis of Wilms tumors: results from the first National Wilms’ Tumor Study. Cancer. 1978;41:1937‐1948.
    1. Faria P, Beckwith JB, Mishra K, et al. Focal versus diffuse anaplasia in Wilms tumor—new definitions with prognostic significance: a report from the National Wilms Tumor Study Group. Am J Surg Pathol. 1996;20:909‐920.
    1. Vujanic GM, Harms D, Sandstedt B, et al. New definitions of focal and diffuse anaplasia in Wilms tumor: the International Society of Paediatric Oncology (SIOP) experience. Med Pediatr Oncol. 1999;32:317‐323.
    1. Bonadio JF, Storer B, Norkool P, et al. Anaplastic Wilms' tumor: clinical and pathologic studies. J Clin Oncol. 1985;3:513‐520.
    1. Zuppan CW, Beckwith JB, Luckey DW. Anaplasia in unilateral Wilms’ tumor: a report from the National Wilms’ Tumor Study pathology center. Hum Pathol. 1988;19:1199‐1209.

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