Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar 28:12:1385726.
doi: 10.3389/fped.2024.1385726. eCollection 2024.

Acid base and metabolic parameters of the umbilical cord blood and cerebral oxygenation immediately after birth

Martin Dusleag  1   2 , Berndt Urlesberger  1   2 , Bernhard Schwaberger  1   2 , Nariae Baik-Schneditz  1   2 , Christoph Schlatzer  1   2 , Christina H Wolfsberger  1   2 , Gerhard Pichler  1   2
Affiliations

Acid base and metabolic parameters of the umbilical cord blood and cerebral oxygenation immediately after birth

Martin Dusleag et al. Front Pediatr. .

Abstract

Objective: Aim was to investigate whether acid-base and metabolic parameters obtained from arterial umbilical cord blood affect cerebral oxygenation after birth in preterm neonates with respiratory support and in term neonates without respiratory support.

Study design: This was a post-hoc analysis of secondary outcome parameters of a prospective observational study including preterm neonates with and term neonates without respiratory support. Non-asphyxiated neonates with cerebral oxygenation measured with near-infrared spectroscopy during the first 15 min and with blood gas analyses from arterial umbilical cord blood were included. Arterial oxygen saturation (SpO2) and heart rate (HR) were monitored with pulse oximetry. Potential correlations were investigated between acid-base and metabolic parameters (pH-value, bicarbonate, base-excess, and lactate) and crSO2/cFTOE 5 min after birth.

Results: Seventy-seven neonates were included: 14 preterm neonates with respiratory support (mean gestational age [GA] 31.4 ± 4.1 weeks; mean birth weight [BW] 1,690 ± 640 g) and 63 term neonates without respiratory support (GA 38.7 ± 0.8 weeks; BW 3,258 ± 443 g). Mean crSO2 5 min after birth was 44.0% ± 24.2% in preterm and 62.2% ± 20.01% in term neonates. Mean cFTOE 5 min after birth was 0.46 ± 0.06 in preterm and 0.27 ± 0.19 in term neonates. In preterm neonates with respiratory support higher lactate was significantly associated with lower crSO2 and SpO2 and tended to be associated with higher cFTOE. In term neonates without respiratory support no significant correlations were found.

Conclusion: In non-asphyxiated preterm neonates with respiratory support, lactate levels were negatively associated with crSO2 and SpO2, whereas in term neonates without respiratory support no associations were observed.

Keywords: acid-base and metabolic parameters; cerebral oxygenation; immediate neonatal transition; near-infrared spectroscopy; neonates.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Patient flow diagram. NIRS, near infrared spectrometry.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Rudolph AM. Fetal and neonatal pulmonary circulation. Annu Rev Physiol. (1979) 41:383–95. 10.1146/annurev.ph.41.030179.002123 - DOI - PubMed
    1. Apgar V. A proposal for a new method of evaluation of the newborn infant. Curr Res Anesth Analg. (1953) 32(4):260–7. 10.1213/ANE.0b013e31829bdc5c - DOI - PubMed
    1. Pichler G, Schmölzer GM, Urlesberger B. Cerebral tissue oxygenation during immediate neonatal transition and resuscitation. Front Pediatr. (2017) 5:29. 10.3389/fped.2017.00029 - DOI - PMC - PubMed
    1. Wyllie J, Bruinenberg J, Roehr CC, Rüdiger M, Trevisanuto D, Urlesberger B. European resuscitation council guidelines for resuscitation 2015: section 7. Resuscitation and support of transition of babies at birth. Resuscitation. (2015) 95:249–63. 10.1016/j.resuscitation.2015.07.029 - DOI - PubMed
    1. Wyckoff MH, Aziz K, Escobedo MB, Kapadia VS, Kattwinkel J, Perlman JM. Part 13: neonatal resuscitation: 2015 American heart association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. (2015) 132(18 Suppl 2):S543–60. 10.1161/CIR.0000000000000252 - DOI - PubMed

LinkOut - more resources