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Review
. 2024 Mar 22;14(7):557.
doi: 10.3390/nano14070557.

Current Advances of Nanomaterial-Based Oral Drug Delivery for Colorectal Cancer Treatment

Nuoya Wang  1   2   3 , Liqing Chen  1   2 , Wei Huang  1   2 , Zhonggao Gao  1   2 , Mingji Jin  1   2
Affiliations
Review

Current Advances of Nanomaterial-Based Oral Drug Delivery for Colorectal Cancer Treatment

Nuoya Wang et al. Nanomaterials (Basel). .

Abstract

Colorectal cancer (CRC) is a common malignant tumor, and traditional treatments include surgical resection and radiotherapy. However, local recurrence, distal metastasis, and intestinal obstruction are significant problems. Oral nano-formulation is a promising treatment strategy for CRC. This study introduces physiological and environmental factors, the main challenges of CRC treatment, and the need for a novel oral colon-targeted drug delivery system (OCDDS). This study reviews the research progress of controlled-release, responsive, magnetic, targeted, and other oral nano-formulations in the direction of CRC treatment, in addition to the advantages of oral colon-targeted nano-formulations and concerns about the oral delivery of related therapeutic agents to inspire related research.

Keywords: colorectal cancer; nano-drug delivery system; oral; oral colon-targeted drug delivery system (OCDDS).

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The scheme represents physiological environmental factors and major challenges for CRC therapy.
Figure 2
Figure 2
Schematic representation of the preparation of Gd-MHAPNPs and the mechanism of drug release from different physiological environments in GIT [50]. Reprinted with permission from [50].
Figure 3
Figure 3
Schematic representation of the drug loading of MNPs and drug release upon application of external stimuli [65]. Author opens copyright and authorizes reprinting from [65].
Figure 4
Figure 4
Structure of three common anticancer drugs 5-FU, oxaliplatin, and irinotecan for treating colon cancer via MNPs [65]. Author opens copyright and authorizes reprinting from [65].
Figure 5
Figure 5
Schematic representation of CD133-targeted nanoparticle delivery mechanism [77]. Reprinted with permission from [77].
See this image and copyright information in PMC

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