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. 1985 Aug;82(15):5180-4.
doi: 10.1073/pnas.82.15.5180.

Duck hepatitis B virus DNA in liver and serum of Chinese ducks: integration of viral DNA in a hepatocellular carcinoma

O Yokosuka, M Omata, Y Z Zhou, F Imazeki, K Okuda

Duck hepatitis B virus DNA in liver and serum of Chinese ducks: integration of viral DNA in a hepatocellular carcinoma

O Yokosuka et al. Proc Natl Acad Sci U S A. 1985 Aug.

Abstract

The presence of duck hepatitis B virus (DHBV) DNA in liver and serum and its state (integrated vs. free) were studied in 23 ducks from Chi-tung county in China by spot hybridization and Southern blot hybridization, respectively. In 16 of 23 (70%), DHBV DNA was detected in serum and/or in liver tissue. These infected ducks showed a variety of pathological changes including advanced chronic disease in the liver. In contrast, none of the virus-negative ducks had advanced hepatic changes. One DHBV DNA-seropositive duck had a large hepatocellular carcinoma. Southern blot analysis demonstrated integrated DHBV DNA in neoplastic tissue and abundant episomal DHBV DNA in non-neoplastic tissue of the liver. In one noninfected duck with a small adenoma, no viral DNA was detected in tumor or non-neoplastic tissue. The detection of integrated DHBV DNA in hepatocellular carcinoma suggests that DHBV behaves like human and woodchuck hepatitis viruses in relation to chronic liver disease and hepatocarcinogenesis.

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References

    1. J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed
    1. Hepatology. 1984 Jul-Aug;4(4):603-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Aug;76(8):3683-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 May;77(5):2941-5 - PubMed
    1. Nature. 1980 Jul 31;286(5772):531-3 - PubMed

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