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. 2024 Nov;34(6):871-890.
doi: 10.1111/ipd.13188. Epub 2024 Apr 12.

Diagnosis and initial management of children presenting with premature loss of primary teeth associated with a systemic condition: A scoping review and development of clinical aid

Claudia Heggie  1 , Hiba Al-Diwani  1 , Paul Arundel  2 , Richard Balmer  1
Affiliations
Free article

Diagnosis and initial management of children presenting with premature loss of primary teeth associated with a systemic condition: A scoping review and development of clinical aid

Claudia Heggie et al. Int J Paediatr Dent. 2024 Nov.
Free article

Abstract

Background: Premature loss of primary teeth (PLPT) can be a rare presentation of systemic medical conditions. Premature loss of primary teeth may present a diagnostic dilemma to paediatric dentists.

Aims: To identify systemic conditions associated with PLPT and develop a clinical aid.

Design: OVID Medline, Embase and Web of Science were searched up to March 2023. Citation searching of review publications occurred. Exclusion occurred for conference abstracts, absence of PLPT and absence of English-language full text.

Results: Seven hundred and ninety-one publications were identified via databases and 476 by citation searching of review articles. Removal of 390 duplicates occurred. Following the exclusion of 466 records on abstract review, 411 publications were sought for retrieval, of which 142 met inclusion criteria. Thirty-one systemic conditions were identified. For 19 conditions, only one publication was identified. The majority of publications, 91% (n = 129), were case reports or series. Most publications, 44% (n = 62), were related to hypophosphatasia, and 25% (n = 35) were related to Papillon-Lefèvre. Diagnostic features were synthesised, and a clinical aid was produced by an iterative consensus approach.

Conclusions: A diverse range of systemic diseases are associated with PLPT. Evidence quality, however, is low, with most diseases having a low number of supporting cases. This clinical aid supports paediatric dentists in differential diagnosis and onward referral.

Keywords: dental development; medical compromise; premature exfoliation; primary teeth; systemic disease; tooth loss.

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References

REFERENCES

    1. Ripa LW, Leske GS, Sposato AL, Simon GA, Moresco TV. Chronology and sequence of exfoliation of primary teeth. J Am Dent Assoc. 1982;105(4):641‐644.
    1. Hartsfield JK Jr. Premature exfoliation of teeth in childhood and adolescence. Adv Pediatr. 1994;41:453‐470.
    1. American Academy of pediatric dentistry. Dental Growth and Development 2003 Available from: https://www.aapd.org/globalassets/media/policies_guidelines/r_dentalgrow....
    1. Spodzieja K, Olczak‐Kowalczyk D. Premature loss of deciduous teeth as a symptom of systemic disease: a narrative literature review. Int J Environ Res Public Health. 2022;19(6):3386.
    1. Ashri NY. Early diagnosis and treatment options for the periodontal problems in Papillon‐Lefèvre syndrome: a literature review. J Int Acad Periodontol. 2008;10(3):81‐86.

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