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Review
. 2024 Nov;23(4):419-428.
doi: 10.1007/s10689-024-00383-2. Epub 2024 Apr 12.

Understanding familial risk of pancreatic ductal adenocarcinoma

Raymond M Paranal  1   2 , Laura D Wood  1   3 , Alison P Klein #  4   5   6 , Nicholas J Roberts #  7   8
Affiliations
Review

Understanding familial risk of pancreatic ductal adenocarcinoma

Raymond M Paranal et al. Fam Cancer. 2024 Nov.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease that is the result of an accumulation of sequential genetic alterations. These genetic alterations can either be inherited, such as pathogenic germline variants that are associated with an increased risk of cancer, or acquired, such as somatic mutations that occur during the lifetime of an individual. Understanding the genetic basis of inherited risk of PDAC is essential to advancing patient care and outcomes through improved clinical surveillance, early detection initiatives, and targeted therapies. In this review we discuss factors associated with an increased risk of PDAC, the prevalence of genetic variants associated with an increased risk in patients with PDAC, estimates of PDAC risk in carriers of pathogenic germline variants in genes associated with an increased risk of PDAC. The role of common variants in pancreatic cancer risk will also be discussed.

Keywords: Cancer; Genetics; Pancreas; Risk; Surveillance.

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Conflict of interest statement

Conflict of Interest

Dr. Nicholas Roberts is a Section Editor (Cancer Genomics) for Annals of Pancreatic Cancer.

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