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Review
. 2024 Mar 26;13(7):1916.
doi: 10.3390/jcm13071916.

A Review on the Feasibility and Efficacy of Home-Based Cognitive Remediation in People with Multiple Sclerosis

Angela Boschetti  1   2 , Elisabetta Maida  3 , Michelangelo Dini  1   2 , Marta Tacchini  1   2 , Giulia Gamberini  4 , Giancarlo Comi  4 , Letizia Leocani  1   2   4
Affiliations
Review

A Review on the Feasibility and Efficacy of Home-Based Cognitive Remediation in People with Multiple Sclerosis

Angela Boschetti et al. J Clin Med. .

Abstract

Cognitive impairment affects 34-65% of People with Multiple Sclerosis (PwMS), significantly impacting their quality of life. Clinicians routinely address cognitive deficits with in-clinic neuro-behavioural interventions, but accessibility issues exist. Given these challenges, coupled with the lifelong need for continuous assistance in PwMS, researchers have underscored the advantageous role of telerehabilitation in addressing these requirements. Nonetheless, the feasibility and efficacy of home-based cognitive remediation remain to be firmly established. In this narrative review, we aimed to investigate the feasibility and efficacy of digital telerehabilitation for cognition in PwMS. Thirteen relevant studies were identified and carefully assessed. Regarding the feasibility of cognitive telerehabilitation, evidence shows adherence rates are generally good, although, surprisingly, not all studies reported measures of compliance with the cognitive training explored. Considering the efficacy of rehabilitative techniques on cognitive performance in PwMS, findings are generally inconsistent, with only one study reporting uniformly positive results. A range of methodological limitations are reported as potential factors contributing to the variable results. Future research must address these challenges, as more rigorous studies are required to draw definitive conclusions regarding the efficacy of home-based cognitive remediation in PwMS. Researchers must prioritise identifying optimal intervention approaches and exploring the long-term effects of telerehabilitation.

Keywords: cognitive remediation; efficacy; feasibility; multiple sclerosis; telerehabilitation.

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Conflict of interest statement

GC. has received consulting and speaking fees from Biogen, Merck, Novartis, Roche, Sanofi-Genzyme, Almirall, Teva, Actelion, Cellgene, BMS and Janssen. L.L. received research support from Novartis, Almirall, Biogen, and Merck and consultancy or speaker fees from Novartis, Almirall, Biogen, Merck, Janssen-Cilag, Bristol-Myers Squibb, and Roche. All other authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Intensity of digital telerehabilitation [6,46,53,54,55,56,57,58,59,60,61,62,63].
See this image and copyright information in PMC

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