The Contribution of Proteomics in Understanding Endometrial Protein Expression in Women with Recurrent Implantation Failure

doi:10.3390/jcm13072145

Review

. 2024 Apr 8;13(7):2145.

doi: 10.3390/jcm13072145.

The Contribution of Proteomics in Understanding Endometrial Protein Expression in Women with Recurrent Implantation Failure

Affiliations

¹ Third Department of Obstetrics and Gynecology, Medical School, University General Hospital "ATTIKON", National and Kapodistrian University of Athens, 12462 Athens, Greece.
² First Department of Obstetrics and Gynecology, Medical School, Alexandra Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.
³ Department of Obstetrics and Gynecology, Royal Cornwall Hospital, Treliske, Truro TR1 3LQ, UK.
⁴ Department of Obstetrics and Gynecology, Medical School of the University of Ioannina, 45110 Ioannina, Greece.

PMID: 38610911
PMCID: PMC11012239
DOI: 10.3390/jcm13072145

Review

The Contribution of Proteomics in Understanding Endometrial Protein Expression in Women with Recurrent Implantation Failure

Anastasios Potiris et al. J Clin Med. 2024.

. 2024 Apr 8;13(7):2145.

doi: 10.3390/jcm13072145.

Affiliations

¹ Third Department of Obstetrics and Gynecology, Medical School, University General Hospital "ATTIKON", National and Kapodistrian University of Athens, 12462 Athens, Greece.
² First Department of Obstetrics and Gynecology, Medical School, Alexandra Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.
³ Department of Obstetrics and Gynecology, Royal Cornwall Hospital, Treliske, Truro TR1 3LQ, UK.
⁴ Department of Obstetrics and Gynecology, Medical School of the University of Ioannina, 45110 Ioannina, Greece.

PMID: 38610911
PMCID: PMC11012239
DOI: 10.3390/jcm13072145

Abstract

Recurrent implantation failure (RIF) poses a significant challenge in assisted reproductive technology (ART) outcomes. The endometrium plays a crucial role in embryo implantation, and its protein expression profile is integral in determining receptivity. Proteomics has emerged as a valuable tool in unraveling the molecular intricacies underlying endometrial receptivity and RIF. The aim of the present review is to analyze the contribution of proteomics to the understanding of endometrial protein expression in women with RIF, based on the results of significant proteomic studies. Medline/Pubmed databases were searched using keywords pertaining to proteomics combined with terms related to RIF. 15 studies were included in the present review. Several proteins have been found to exbibit differential expression in endometrial biopsies and fluid samples between fertile women and women with RIF during the receptive endometrial phase. The profile of endometrial proteins varied significantly among the studies. Nevertheless, similar changes in the expression levels of annexin-6, progesterone receptor, MMP-2, and MMP-9 in the endometrium of women with RIF, were found in more than one study indicating that certain proteins could potentially be effective biomarkers of endometrial receptivity. Proteomics contributes significantly to the understanding of protein expression in the endometrium of women with RIF and the analysis of proteins in endometrial fluid are promising for improving the clinical management of RIF.

Keywords: biomarkers; endometrial protein expression; endometrial receptivity; proteomics; recurrent implantation failure (RIF).

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Conflict of interest statement

The authors declare no conflicts of interest.

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References

1. Busnelli A., Reschini M., Cardellicchio L., Vegetti W., Somigliana E., Vercellini P. How common is real repeated implantation failure? An indirect estimate of the prevalence. Reprod. Biomed. Online. 2020;40:91–97. doi: 10.1016/j.rbmo.2019.10.014. - DOI - PubMed
1. Coughlan C., Ledger W., Wang Q., Liu F., Demirol A., Gurgan T., Cutting R., Ong K., Sallam H., Li T.C. Recurrent implantation failure: Definition and management. Reprod. Biomed. Online. 2014;28:14–38. doi: 10.1016/j.rbmo.2013.08.011. - DOI - PubMed
1. Cimadomo D., de Los Santos M.J., Griesinger G., Lainas G., Le Clef N., McLernon D.J., Montjean D., Toth B., Vermeulen N., Macklon N., et al. ESHRE good practice recommendations on recurrent implantation failure. Hum. Reprod. Open. 2023;2023:hoad023. doi: 10.1093/hropen/hoad023. - DOI - PMC - PubMed
1. Vaduva C.C., Constantinescu C., Serbanescu M., Dara L., Oancea M.D., Carp-Veliscu A. The association between endometrial polyps, chronic endometritis, and IVF outcomes. Eur. Rev. Med. Pharmacol. Sci. 2023;27:8895–8904. doi: 10.26355/eurrev_202309_33810. - DOI - PubMed
1. Buzzaccarini G., Vitagliano A., Andrisani A., Santarsiero C.M., Cicinelli R., Nardelli C., Ambrosini G., Cicinelli E. Chronic endometritis and altered embryo implantation: A unified pathophysiological theory from a literature systematic review. J. Assist. Reprod. Genet. 2020;37:2897–2911. doi: 10.1007/s10815-020-01955-8. - DOI - PMC - PubMed

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[1] Busnelli A., Reschini M., Cardellicchio L., Vegetti W., Somigliana E., Vercellini P. How common is real repeated implantation failure? An indirect estimate of the prevalence. Reprod. Biomed. Online. 2020;40:91–97. doi: 10.1016/j.rbmo.2019.10.014. - DOI - PubMed

[2] Busnelli A., Reschini M., Cardellicchio L., Vegetti W., Somigliana E., Vercellini P. How common is real repeated implantation failure? An indirect estimate of the prevalence. Reprod. Biomed. Online. 2020;40:91–97. doi: 10.1016/j.rbmo.2019.10.014. - DOI - PubMed

[3] Coughlan C., Ledger W., Wang Q., Liu F., Demirol A., Gurgan T., Cutting R., Ong K., Sallam H., Li T.C. Recurrent implantation failure: Definition and management. Reprod. Biomed. Online. 2014;28:14–38. doi: 10.1016/j.rbmo.2013.08.011. - DOI - PubMed

[4] Coughlan C., Ledger W., Wang Q., Liu F., Demirol A., Gurgan T., Cutting R., Ong K., Sallam H., Li T.C. Recurrent implantation failure: Definition and management. Reprod. Biomed. Online. 2014;28:14–38. doi: 10.1016/j.rbmo.2013.08.011. - DOI - PubMed

[5] Cimadomo D., de Los Santos M.J., Griesinger G., Lainas G., Le Clef N., McLernon D.J., Montjean D., Toth B., Vermeulen N., Macklon N., et al. ESHRE good practice recommendations on recurrent implantation failure. Hum. Reprod. Open. 2023;2023:hoad023. doi: 10.1093/hropen/hoad023. - DOI - PMC - PubMed

[6] Cimadomo D., de Los Santos M.J., Griesinger G., Lainas G., Le Clef N., McLernon D.J., Montjean D., Toth B., Vermeulen N., Macklon N., et al. ESHRE good practice recommendations on recurrent implantation failure. Hum. Reprod. Open. 2023;2023:hoad023. doi: 10.1093/hropen/hoad023. - DOI - PMC - PubMed

[7] Vaduva C.C., Constantinescu C., Serbanescu M., Dara L., Oancea M.D., Carp-Veliscu A. The association between endometrial polyps, chronic endometritis, and IVF outcomes. Eur. Rev. Med. Pharmacol. Sci. 2023;27:8895–8904. doi: 10.26355/eurrev_202309_33810. - DOI - PubMed

[8] Vaduva C.C., Constantinescu C., Serbanescu M., Dara L., Oancea M.D., Carp-Veliscu A. The association between endometrial polyps, chronic endometritis, and IVF outcomes. Eur. Rev. Med. Pharmacol. Sci. 2023;27:8895–8904. doi: 10.26355/eurrev_202309_33810. - DOI - PubMed

[9] Buzzaccarini G., Vitagliano A., Andrisani A., Santarsiero C.M., Cicinelli R., Nardelli C., Ambrosini G., Cicinelli E. Chronic endometritis and altered embryo implantation: A unified pathophysiological theory from a literature systematic review. J. Assist. Reprod. Genet. 2020;37:2897–2911. doi: 10.1007/s10815-020-01955-8. - DOI - PMC - PubMed

[10] Buzzaccarini G., Vitagliano A., Andrisani A., Santarsiero C.M., Cicinelli R., Nardelli C., Ambrosini G., Cicinelli E. Chronic endometritis and altered embryo implantation: A unified pathophysiological theory from a literature systematic review. J. Assist. Reprod. Genet. 2020;37:2897–2911. doi: 10.1007/s10815-020-01955-8. - DOI - PMC - PubMed

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The Contribution of Proteomics in Understanding Endometrial Protein Expression in Women with Recurrent Implantation Failure

Affiliations

The Contribution of Proteomics in Understanding Endometrial Protein Expression in Women with Recurrent Implantation Failure

Authors

Affiliations

Abstract

Conflict of interest statement

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Abstract

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References

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