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Review
. 2024 Mar 28;16(7):1313.
doi: 10.3390/cancers16071313.

Targeting Dysregulated Lipid Metabolism in Cancer with Pharmacological Inhibitors

Amogh Gupta  1 , Dipanwita Das  1 , Reshma Taneja  1
Affiliations
Review

Targeting Dysregulated Lipid Metabolism in Cancer with Pharmacological Inhibitors

Amogh Gupta et al. Cancers (Basel). .

Abstract

Metabolic plasticity is recognised as a hallmark of cancer cells, enabling adaptation to microenvironmental changes throughout tumour progression. A dysregulated lipid metabolism plays a pivotal role in promoting oncogenesis. Oncogenic signalling pathways, such as PI3K/AKT/mTOR, JAK/STAT, Hippo, and NF-kB, intersect with the lipid metabolism to drive tumour progression. Furthermore, altered lipid signalling in the tumour microenvironment contributes to immune dysfunction, exacerbating oncogenesis. This review examines the role of lipid metabolism in tumour initiation, invasion, metastasis, and cancer stem cell maintenance. We highlight cybernetic networks in lipid metabolism to uncover avenues for cancer diagnostics, prognostics, and therapeutics.

Keywords: cancer stem cells; epigenetics; lipid signalling; metastasis; therapeutics.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Lipid metabolism targeting for cancer therapy. (A). Fatty acid synthesis. (B). Fatty acid oxidation. (C). Cholesterol metabolism. (D). Fatty acid uptake. Molecules highlighted in red show potential targetable leads for dysregulated lipid metabolism in cancers.
See this image and copyright information in PMC

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