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Review
. 2024 Mar 28;16(7):1330.
doi: 10.3390/cancers16071330.

Immune Response and Metastasis-Links between the Metastasis Driver MACC1 and Cancer Immune Escape Strategies

Sebastian Torke  1 , Wolfgang Walther  1 , Ulrike Stein  1
Affiliations
Review

Immune Response and Metastasis-Links between the Metastasis Driver MACC1 and Cancer Immune Escape Strategies

Sebastian Torke et al. Cancers (Basel). .

Abstract

Metastasis remains the most critical factor limiting patient survival and the most challenging part of cancer-targeted therapy. Identifying the causal drivers of metastasis and characterizing their properties in various key aspects of cancer biology is essential for the development of novel metastasis-targeting approaches. Metastasis-associated in colon cancer 1 (MACC1) is a prognostic and predictive biomarker that is now recognized in more than 20 cancer entities. Although MACC1 can already be linked with many hallmarks of cancer, one key process-the facilitation of immune evasion-remains poorly understood. In this review, we explore the direct and indirect links between MACC1 and the mechanisms of immune escape. Therein, we highlight the signaling pathways and secreted factors influenced by MACC1 as well as their effects on the infiltration and anti-tumor function of immune cells.

Keywords: MACC1; immune evasion; metastasis.

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Conflict of interest statement

All authors declare no conflict of interests.

Figures

Figure 1
Figure 1
Links between MACC1 and mechanisms of immune escape. MACC1 directly affects the expression or function of the indicated factors, which in turn leads to immunological consequences marked by the arrows. Up- (green arrow pointing upward) or downregulation (red arrow pointing downward) are next to the immunologically relevant markers. Consequently, this affects the tumor microenvironment and creates a tumor-favorable milieu.
See this image and copyright information in PMC

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