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Review
. 2024 Mar 29;16(7):1346.
doi: 10.3390/cancers16071346.

Risk-Tailoring Radiotherapy for Endometrial Cancer: A Narrative Review

Kristin Hsieh  1 , Julie R Bloom  1 , Daniel R Dickstein  1 , Anuja Shah  1 , Catherine Yu  1 , Anthony D Nehlsen  1 , Lucas Resende Salgado  1 , Vishal Gupta  1 , Manjeet Chadha  1 , Kunal K Sindhu  1
Affiliations
Review

Risk-Tailoring Radiotherapy for Endometrial Cancer: A Narrative Review

Kristin Hsieh et al. Cancers (Basel). .

Abstract

Endometrial cancer is the most common gynecologic cancer in the United States and it contributes to the second most gynecologic cancer-related deaths. With upfront surgery, the specific characteristics of both the patient and tumor allow for risk-tailored treatment algorithms including adjuvant radiotherapy and systemic therapy. In this narrative review, we discuss the current radiation treatment paradigm for endometrial cancer with an emphasis on various radiotherapy modalities, techniques, and dosing regimens. We then elaborate on how to tailor radiotherapy treatment courses in combination with other cancer-directed treatments, including chemotherapy and immunotherapy. In conclusion, this review summarizes ongoing research that aims to further individualize radiotherapy regimens for individuals in an attempt to improve patient outcomes.

Keywords: endometrial cancer; personalized treatment; radiation oncology; radiation-induced toxicities; radiotherapy; risk-tailoring; uterine malignancy.

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Conflict of interest statement

K.H. is supported by the 2023 ASTRO-AstraZeneca Radiation Oncology Research Training Fellowship Program. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. The remaining authors declare no conflicts of interest.

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