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Review
. 2024 Apr 4;25(7):4014.
doi: 10.3390/ijms25074014.

SLAM Family Receptors in B Cell Chronic Lymphoproliferative Disorders

Dominik Kľoc  1 , Slavomír Kurhajec  2 , Mykhailo Huniadi  1 , Ján Sýkora  3 , Tomáš Guman  3 , Marek Šarišský  1
Affiliations
Review

SLAM Family Receptors in B Cell Chronic Lymphoproliferative Disorders

Dominik Kľoc et al. Int J Mol Sci. .

Abstract

The signaling lymphocytic activation molecule (SLAM) receptor family (SLAMF) consists of nine glycoproteins that belong to the CD2 superfamily of immunoglobulin (Ig) domain-containing molecules. SLAMF receptors modulate the differentiation and activation of a wide range of immune cells. Individual SLAMF receptors are expressed on the surface of hematopoietic stem cells, hematopoietic progenitor cells, B cells, T cells, NK cells, NKT cells, monocytes, macrophages, dendritic cells, neutrophils, and platelets. The expression of SLAMF receptors was studied during normal B cell maturation. Several SLAMF receptors were also detected in cancer cell lines of B-lymphoid origin and in pathological B cells from patients with B cell chronic lymphoproliferative disorders (B-CLPD), the most frequent hematological malignancies in adults. This review summarizes current knowledge on the expression of SLAMF receptors and their adaptor proteins SAP and EAT-2 in B-CLPD. Several SLAMF receptors could be regarded as potential diagnostic and differential diagnostic markers, prognostic factors, and targets for the development of novel drugs for patients with B-CLPD.

Keywords: B cell chronic lymphoproliferative disorders; B cells; B-CLPD; EAT-2; SAP; SLAM family receptors; SLAMF; flow cytometry; leukemia; lymphoma.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The schematic structure of SLAM family receptors.
See this image and copyright information in PMC

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