The Profound Influence of Gut Microbiome and Extracellular Vesicles on Animal Health and Disease

Abstract

The animal gut microbiota, comprising a diverse array of microorganisms, plays a pivotal role in shaping host health and physiology. This review explores the intricate dynamics of the gut microbiome in animals, focusing on its composition, function, and impact on host-microbe interactions. The composition of the intestinal microbiota in animals is influenced by the host ecology, including factors such as temperature, pH, oxygen levels, and nutrient availability, as well as genetic makeup, diet, habitat, stressors, and husbandry practices. Dysbiosis can lead to various gastrointestinal and immune-related issues in animals, impacting overall health and productivity. Extracellular vesicles (EVs), particularly exosomes derived from gut microbiota, play a crucial role in intercellular communication, influencing host health by transporting bioactive molecules across barriers like the intestinal and brain barriers. Dysregulation of the gut-brain axis has implications for various disorders in animals, highlighting the potential role of microbiota-derived EVs in disease progression. Therapeutic approaches to modulate gut microbiota, such as probiotics, prebiotics, microbial transplants, and phage therapy, offer promising strategies for enhancing animal health and performance. Studies investigating the effects of phage therapy on gut microbiota composition have shown promising results, with potential implications for improving animal health and food safety in poultry production systems. Understanding the complex interactions between host ecology, gut microbiota, and EVs provides valuable insights into the mechanisms underlying host-microbe interactions and their impact on animal health and productivity. Further research in this field is essential for developing effective therapeutic interventions and management strategies to promote gut health and overall well-being in animals.

Keywords: animal; dysbiosis; extracellular vesicles; gut microbiome; immune system regulation.

Figure 1

Environmental factors such as temperature, pH, oxygen levels, and nutrient availability profoundly shape the composition and diversity of the intestinal microbiota in animals, influencing their health and metabolism. Gut microbiota-derived extracellular vesicles (EVs), particularly exosomes, play crucial roles in intercellular communication, impacting immune response, neuroinflammation, and metabolic dysfunction. Therapeutic interventions like probiotics, prebiotics, microbial transplants, organic acids, and phage therapy offer promising avenues for modulating the gut microbiota, improving growth performance, health outcomes, and disease resilience in animals.