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. 1979 Oct 18;281(5732):544-8.
doi: 10.1038/281544a0.

Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone

D V Goeddel, H L Heyneker, T Hozumi, R Arentzen, K Itakura, D G Yansura, M J Ross, G Miozzari, R Crea, P H Seeburg

Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone

D V Goeddel et al. Nature. .

Abstract

DNA coding for human growth hormone was constructed by using chemically synthesised DNA in conjunction with enzymatically prepared cDNA. This 'hybrid' gene was expressed in Escherichia coli under the control of the lac promoter. A polypeptide was produced having the size and immunological properties characteristic of mature human growth hormone.

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