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Case Reports
. 2024 Apr 10:17:327-338.
doi: 10.2147/OTT.S453698. eCollection 2024.

Primary Epithelioid Angiosarcoma of the Jejunal Mesentery Causing Abdominal Bleeding: Case Report and Literature Review

Peiyuan Yang  1 , Qiong Wu  2 , Yang Zhou  1 , Yongchao Li  1
Affiliations
Case Reports

Primary Epithelioid Angiosarcoma of the Jejunal Mesentery Causing Abdominal Bleeding: Case Report and Literature Review

Peiyuan Yang et al. Onco Targets Ther. .

Abstract

Gastrointestinal angiosarcoma is an extremely rare malignant tumor of the digestive tract, characterized by a very poor prognosis, with few patients surviving more than 1 year after diagnosis. This case report describes a 71-year-old female patient with a 3-year history of intermittent abdominal pain and significant exacerbation of abdominal pain and bloating 2 weeks prior to treatment. After surgical treatment, the pathological and immunohistochemical diagnosis was primary epithelioid angiosarcoma of the jejunal mesentery. The patient refused postoperative adjuvant chemotherapy and died 4 months after diagnosis due to widespread systemic metastasis. In addition, this article reviews 38 previously reported cases of primary gastrointestinal angiosarcoma, aiming to further understand angiosarcoma and thus guide clinical practitioners in providing more comprehensive treatment approaches.

Keywords: angiosarcoma; gastrointestinal; hematochezia.

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Conflict of interest statement

The authors declare that they have no competing interests in this work.

Figures

Figure 1
Figure 1
Abdominal computed tomography shows a slightly high-density heterogeneous mass of 9.3 * 5.9cm in the small intestine, with a density ranging from 34 to 57HU, indicated by yellow arrows (a). Enhanced scanning shows mild heterogeneous enhancement of the tumor, indicated by blue arrows (b).
Figure 2
Figure 2
During the operation, a dark red mass was found on the left side of the upper abdomen, with some of the greater omentum adhering to it. It was approximately 90 cm away from the Treitz ligament and was approximately 10 * 6cm in size (yellow arrows).
Figure 3
Figure 3
The lesion is located in the empty mesangium, with spindle shaped tumor cells and obvious atypia, indicated by yellow arrows (a). Tumor cells surround irregular blood vessel cavities, with green arrows (b and c). Some areas of the tumor show bleeding foci, indicated by blue arrows (d).
Figure 4
Figure 4
Immunohistochemical staining showed that tumor cells expressed CD31(a), CD34(b), Fli-1(c), MDM2(d), ERG(e), and INI1(f).
See this image and copyright information in PMC

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