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. 1985 Sep;38(3):369-81.
doi: 10.1002/jlb.38.3.369.

Enhanced activity of the macrophage-like cell line J774.1 following exposure to gamma radiation

E K Gallin, S W Green, P A Sheehy

Enhanced activity of the macrophage-like cell line J774.1 following exposure to gamma radiation

E K Gallin et al. J Leukoc Biol. 1985 Sep.

Abstract

Exposure of the macrophage-like cell line J774.1 to 20 gray of cobalt-60 gamma radiation resulted in a block of tritiated thymidine incorporation, along with an increase in cell "activation," as assessed by increases in lysosomal enzyme and ectoenzyme content, PMA-induced H2O2 production, and NBT staining, ingestion of E(IgG), spreading, and membrane ruffling. These changes are evident within 1 day postradiation and peak at 4 days postradiation.

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