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Review

New Drugs IV

No authors listed
Tom Perry
, editors.
In: Therapeutics Letter. Vancouver (BC): Therapeutics Initiative; 1994. Letter 26.
1998 Oct.
Review

New Drugs IV

No authors listed.

Excerpt

Therapeutics Letter 26 examines benefits and harms of newer drugs donepezil, levofloxacin, pantoprazole, and quetiapine. Donepezil slightly improves a measure of cognitive function and a clinician’s global assessment of change in patients with Alzheimer’s disease. Levofloxacin is similar to ofloxacin in all respects except that it is twice as potent. Pantoprazole is a proton pump inhibitor that is similar in efficacy, safety, cost and convenience to lansoprazole and omeprazole. Quetiapine has similar efficacy and a different side effect profile to haloperidol and chlorpromazine in 6-week trials. More and better evidence is required to demonstrate the long-term effectiveness and safety of new atypical antipsychotics.

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References

    1. Rogers SL, Friedhoff LT. The Efficacy and Safety of Donepezil in Patients with Alzheimer’s Disease: Results of a US Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial .Dementia 1996; 7:293–303. - PubMed
    1. Rogers SL, Farlow, MR, et al. . A 24-week, double-blind, placebo controlled trial of donepezil in patients with Alzheimer’s disease .Neurology 1998; 50:136–145. - PubMed
    1. Rogers SL, Doody RS, Mohs RC, Friedhoff LT. Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study. Donepezil Study Group. Arch Intern Med 1998; 138:1021–1031. - PubMed
    1. M. Verho, et al. . Pharmacokinetics of levofloxacin in comparison to the racemic mixture of ofloxacin in man .Drug Metabolism and Drug Interactions 1996: 13: 57–67. - PubMed
    1. Mossner J. Holscher AH, Herz R, Schneider A. A double-blind study of pantoprazole and omeprazole in the treatment of reflux esophagitis: a multicentre trial .Aliment Pharmacol Ther 1995; 9:321–6. - PubMed