Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jul 1;72(Suppl 4):S592-S595.
doi: 10.4103/IJO.IJO_2724_23. Epub 2024 Apr 16.

Surgically induced necrotizing scleritis (SINS): Is it a standalone condition or a variant of necrotizing scleritis?

Kowsigan Magesan  1 , Parthopratim Dutta Majumder  1 , Mamta Agarwal  2 , Amala E George  1 , Vinita Nair  1 , Sudha K Ganesh  1 , Jyotirmay Biswas  1
Affiliations

Surgically induced necrotizing scleritis (SINS): Is it a standalone condition or a variant of necrotizing scleritis?

Kowsigan Magesan et al. Indian J Ophthalmol. .

Abstract

Purpose: To report the clinical pattern of surgically induced necrotizing scleritis (SINS) in a tertiary eye care center in Southern India.

Methods: Retrospective analysis of all SINS cases visiting the uveitis clinic of a tertiary eye institute between January 2009 and April 2019.

Results: In total, 15 patients with a median age of 65 (IQR: 52-70) years were included in the study. Male (53%) predominance was noted, and SINS was unilateral (100%) in all cases. Most (87%) of the patients developed SINS after a single surgical procedure, with a median onset period of 251 (IQR: 127-1095) days. None of these patients had any evidence of systemic association. Ocular hypertension (n = 3, 20%), and cataract (n = 5, 33%) were the most common complications. When compared with a cohort of patients with idiopathic necrotizing scleritis, the index study did not find any statistically significant difference between SINS and idiopathic scleritis.

Conclusion: SINS is idiopathic necrotizing scleritis rather than an independent entity of scleritis.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

References

    1. McGavin DD, Williamson J, Forrester JV, Foulds WS, Buchanan WW, Dick WC, et al. Episcleritis and scleritis. A study of their clinical manifestations and association with rheumatoid arthritis. Br J Ophthalmol. 1976;60:192–226. - PMC - PubMed
    1. Fong LP, de la Maza MS, Rice BA, Kupferman AE, Foster CS. Immunopathology of Scleritis. Ophthalmology. 1991;98:472–9. - PubMed
    1. Haynes BF, Fishman ML, Fauci AS, Wolff SM. The ocular manifestations of Wegener’s granulomatosis: Fifteen years experience and review of the literature. Am J Med. 1977;63:131–41. - PubMed
    1. de la Maza MS, Foster CS. Necrotizing scleritis after ocular surgery. A clinicopathologic study. Ophthalmology. 1991;98:1720–6. - PubMed
    1. O’Donoghue E, Lightman S, Tuft S, Watson P. Surgically induced necrotising sclerokeratitis (SINS)--Precipitating factors and response to treatment. Br J Ophthalmol. 1992;76:17–21. - PMC - PubMed

LinkOut - more resources