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. 2024 Apr 15;23(1):e0135.
doi: 10.1097/CLD.0000000000000135. eCollection 2024 Jan-Jun.

Neonatal cholestasis: Timely triumph

Shagun Sharma  1 , Kristen Thomas  2 , Frederic Bertino  3 , Jennifer Vittorio  4
Affiliations

Neonatal cholestasis: Timely triumph

Shagun Sharma et al. Clin Liver Dis (Hoboken). .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Jennifer Vittorio consults for and advises Mirum Pharma. The remaining authors have no conflicts to report

Figures

FIGURE 1
FIGURE 1
Percutaneous transhepatic cholecysto-cholangiography (PTCC). [A] Image demonstrates contrast filling the GB and common bile duct (black arrow) with reflux into the PD and free passage into the duodenum (D). Upstream, there is a beaded and truncated appearance of the common hepatic duct (white arrow) without contrast opacification of the intrahepatic bile ducts despite provocative maneuvers. Findings suggest biliary atresia. [B] PTCC is performed in a 1-month-old with normal biliary tree morphology. The needle resides within a normal contrast-opacified GB. A normal common bile duct (black arrow) is shown. Iodinated contrast media flows freely into the duodenum (D). Upstream, there is a normal division of the right and left intrahepatic ducts (white arrows). Abbreviations: D, duodenum; GB, gallbladder; PD, pancreatic duct; PTCC, Percutaneous transhepatic cholecysto-cholangiography.
FIGURE 2
FIGURE 2
Percutaneous liver biopsy demonstrates bile duct injury with portal edema, fibrous expansion of the portal tracts, and prominent ductular reaction (A). Bile duct proliferation is further highlighted by cytokeratin 7 immunohistochemistry (B). Trichrome stain demonstrates focal septal formation (C).
See this image and copyright information in PMC

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