Single-dose ibuprofen induced Stevens-Johnson Syndrome

Abstract

Key clinical message: Ibuprofen single dose may rarely induce Stevens-Johnson Syndrome, emphasizing the vital need for heightened vigilance in healthcare and public awareness for safer medication practices.

Abstract: Stevens-Johnson Syndrome (SJS) is a severe and potentially life-threatening skin disorder associated with certain medications, including ibuprofen. We present a case of a 45-year-old woman who developed SJS following a single dose of ibuprofen. Despite its rarity, this case underscores the importance of heightened vigilance in healthcare and public awareness regarding the potential risks of commonly used medications. Prompt recognition of SJS symptoms and immediate medical intervention are crucial for patient outcomes. Healthcare providers should exercise caution when prescribing ibuprofen, particularly in patients with a history of adverse drug reactions. This case emphasizes the need for ongoing monitoring, patient education, and informed decision-making to promote medication safety and optimal patient care.

Keywords: acute medicine; critical care medicine; dermatology; immunology; pharmacology and pharmacy.

FIGURE 1

Conjunctivitis with discharge. Coalescing red erythematous macules with central blister formation in the face. Chelitis and yellowish discharge.

FIGURE 2

Nonblenching flat purpuric rash with target lesions in lower and upper limbs.

FIGURE 3

Initial Chest X‐ray PA view labeled as normal.

FIGURE 4

Skin biopsy histopathology specimen showing full‐thickness necrosis and separation of the epidermis at the dermoepidermal junction.

FIGURE 5

Decrease in size and color of facial rash with minimal ulcers and normal lips appearance 2 months after admission.