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Review
. 2024 Jul;38(4):258-263.
doi: 10.1177/19458924241246855. Epub 2024 Apr 16.

The Role of Inhalant Allergens on the Clinical Manifestations of Atopic Dermatitis

Jaekeun Jung  1 , Clinton W Enos  2 , Kent K Lam  1 , Joseph K Han  1
Affiliations
Review

The Role of Inhalant Allergens on the Clinical Manifestations of Atopic Dermatitis

Jaekeun Jung et al. Am J Rhinol Allergy. 2024 Jul.

Abstract

Background: Inhalant allergens provide a source of environmental factors that contribute to the development of clinical symptoms in patients with atopic dermatitis (AD).

Objective: To review the relationship between inhalant allergens and AD.

Methods: A literature review was conducted using three databases: PubMed/MEDLINE, ClinicalKey, and Web of Science. Search terms, including "atopic dermatitis," "atopic eczema," and "eczema," were used in combination with "inhalant allergen," "inhaled allergen," and "aeroallergen" to identify relevant published manuscripts that highlight the relationship between AD and exposures to inhalant allergens.

Results: Fifteen articles were suitable for review. The studies included in the review investigated the effect of inhalant allergens on the clinical manifestations of AD through bronchial provocation, direct skin contact, and allergen sensitization.

Conclusion: There is a significant relationship between exposures to inhalant allergens and AD. Inhalant allergens may aggravate AD symptoms by either bronchial provocation or direct skin contact. Sensitization of inhalant allergens, mainly house dust mites, follows a specific age-related pattern.

Keywords: IgE; aeroallergen; atopic dermatitis; atopic eczema; eczema; house dust mite; inhalant allergen; inhaled allergen; pollen; sensitization.

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Conflict of interest statement

Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.