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. 2024 Jun;78(6):1225-1233.
doi: 10.1002/jpn3.12213. Epub 2024 Apr 16.

Esophago-gastric junction findings on high resolution impedance manometry in children with esophageal atresia

Sharman P Tan Tanny  1   2   3 , Nicholas D Senior  1   2   3 , Assia Comella  1   2   4 , Lisa McCall  5 , John M Hutson  1   2   3 , Sue Finch  6 , Mark Safe  1 , Warwick J Teague  1   2   3 , Taher I Omari  5 , Sebastian K King  1   2   3
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Esophago-gastric junction findings on high resolution impedance manometry in children with esophageal atresia

Sharman P Tan Tanny et al. J Pediatr Gastroenterol Nutr. 2024 Jun.

Abstract

Objectives: Using high resolution impedance manometry (HRIM), this study characterized the esophago-gastric junction (EGJ) dynamics in children with esophageal atresia (EA).

Method: Esophageal HRIM was performed in patients with EA aged less than 18 years. Objective motility patterns were analyzed, and EGJ data reported. Controls were pediatric patients without EA undergoing investigations for consideration of fundoplication surgery.

Results: Seventy-five patients (M:F = 43:32, median age 1 year 3 months [3 months-17 years 4 months]) completed 133 HRIM studies. The majority (64/75, 85.3%) had EA with distal tracheo-esophageal fistula. Compared with controls, liquid swallows were poorer in patients with EA, as evident by significant differences in distension pressure emptying and bolus flow time (BFT). The integrated relaxation pressure for thin liquid swallows was significantly different between EA types, as well as when comparing patients with EA with and without previous esophageal dilatations. The BFT for solid swallows was significantly different when compared with EA types.

Conclusions: We have utilized HRIM in patients with EA to demonstrate abnormalities in their long-term EGJ function. These abnormalities correlate with poorer esophageal compliance and reduced esophageal peristalsis across the EGJ. Understanding the EGJ function in patients with EA will allow us to tailor long-term management to specific patients.

Keywords: esophagus; motility; pediatric.

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References

REFERENCES

    1. Riley M, Halliday J. Birth defects in Victoria 2005‐2006. Victorian Perinatal Data Collection Unit. Victoria Government Department of Human Services; 2008.
    1. Rintala RJ. Fundoplication in patients with esophageal atresia: patient selection, indications, and outcomes. Front Pediatr. 2017;5:109.
    1. Pellegrino SA, King SK, McLeod E, et al. Impact of esophageal atresia on the success of fundoplication for gastroesophageal reflux. J Pediatr. 2018;198:60‐66.
    1. Rogers BD, Gyawali CP. Evaluation of the esophagogastric junction on high resolution manometry. J Clin Gastroenterol. 2021;55(2):e8‐e18.
    1. Bagucka B, Badriul H, Vandemaele K, et al. Normal ranges of continuous pH monitoring in the proximal esophagus. J Pediatr Gastroenterol Nutr. 2000;31(3):244‐247.

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