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. 2024 Apr;17(4):e011330.
doi: 10.1161/CIRCHEARTFAILURE.123.011330. Epub 2024 Mar 1.

Mechanically Regulating Cardiac Preload to Maximize Left Ventricular Unloading With a Transvalvular Microaxial Flow Pump

Navin K Kapur  1 , Lara Reyelt  1 , Kay Everett  1 , Elena Mahmoudi  1 , Madison S Kapur  1 , Jacob S Ellis  1 , Lija Swain  1 , Xiaoying Qiao  1 , Shreyas Bhave  1 , Genya Sunagawa  1
Affiliations

Mechanically Regulating Cardiac Preload to Maximize Left Ventricular Unloading With a Transvalvular Microaxial Flow Pump

Navin K Kapur et al. Circ Heart Fail. 2024 Apr.
No abstract available

Keywords: animal; arteries; catheter; hemodynamics; oxygen consumption.

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Conflict of interest statement

Disclosures Dr Kapur receives institutional grant support and consulting/speaking honoraria from Abbott, Abiomed, Boston Scientific, CardiacBooster, Edwards, Getinge, LivaNova, Teleflex, and Zoll. He is co-founder of Precardia Inc (acquired by Abiomed Inc), X-Tension Inc, and Tulyp Inc. All other authors do not have any relevant disclosures.

Figures

Figure.
Figure.
Mechanically Reducing Preload to Augment Left Ventricular Unloading A) Representative pressure-volume loops illustrating reduced left ventricular pressure and volume after activation of the preCARDIA superior vena cava occlusion system in the presence of an Impella CP pump activated, known as PrePella, at P3 or P8 levels of support. B) Pressure-time tracings from the LV (black) and aorta (red) demonstrate reduced aortic pulse pressure and flattening of the tracing during systolic ejection and diastolic filling during PrePella activation. C) Summary of hemodynamic parameters during each condition (n=5 adult swine).
See this image and copyright information in PMC

References

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