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. 2024 Apr 16;19(4):e0298234.
doi: 10.1371/journal.pone.0298234. eCollection 2024.

Epidemiology of congenital heart defects in France from 2013 to 2022 using the PMSI-MCO (French Medical Information System Program in Medicine, Surgery, and Obstetrics) database

Gurvan Bourdon  1 , Xavier Lenne  2 , François Godart  3 , Laurent Storme  4 , Didier Theis  2 , Damien Subtil  5 , Amelie Bruandet  2 , Thameur Rakza  1
Affiliations

Epidemiology of congenital heart defects in France from 2013 to 2022 using the PMSI-MCO (French Medical Information System Program in Medicine, Surgery, and Obstetrics) database

Gurvan Bourdon et al. PLoS One. .

Abstract

Background: Congenital heart defects are common and occur in approximately 0.9% of births. In France, the registries cover approximately 20% of the population but not the entirety of France; therefore, we aimed to update the incidence data for congenital heart defects in France from 2013 to 2022 using the medico-administrative database PMSI-MCO (French Medical Information System Program in Medicine, Surgery, and Obstetrics). We aimed to compare the frequency of risk factors in a population with congenital heart defects and a reference population.

Methods: From 2013 to 2022, we included children aged < 3 years diagnosed with congenital heart defects according to the International Classification of Diseases, 10th Revision, in the PMSI-MCO database. We compared them with a population without congenital defects on several medical data items (e.g., parity, gemellarity, and mortality rate). Bivariate and multivariate analyses compared children with congenital heart defects and children without congenital malformation.

Results: We identified 83,879 children with congenital heart defects in France from 2013 to 2022 in the PMSI-MCO database and 7,739,840 children without such defects, including 7,218,952 without any congenital defects. We observed more deaths (7.49% vs. 0.68%, d = 0.59) and more twinning (8.67% vs. 1.23%, d = 0.35) among children with congenital heart defects. Multivariate analysis revealed an increased risk of congenital heart defects in male individuals (OR [odds ratio] 1.056, 95% CI [confidence interval] [1.039-1.076]) and cases of medically assisted reproduction (OR 1.115, 95% CI [1.045-1.189]) and a reduced risk in the case of multiparity (OR 0.921, 95% CI [0.905-0.938]).

Conclusions: According to the PMSI-MCO database, the incidence of congenital heart defects in France from 2013 to 2022 is 1% of births. Congenital heart defects are more frequent in cases of prematurity, twinning, primiparity, male sex, and maternal age > 40 years.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Results of multivariate analysis in metropolitan France.
Children with congenital heart defects are compared with the reference population from 2013 to 2022. OR: odds ratio; CI: confidence interval.
See this image and copyright information in PMC

References

    1. Dolk H, Loane M, Garne E. The prevalence of congenital anomalies in Europe. Adv Exp Med Biol. 2010;686:349‑64. doi: 10.1007/978-90-481-9485-8_20 - DOI - PubMed
    1. Dolk H, Loane M, Garne E, European Surveillance of Congenital Anomalies (EUROCAT) Working Group. Congenital heart defects in Europe: prevalence and perinatal mortality, 2000 to 2005. Circulation. 2011. Mar 1;123(8):841‑9. - PubMed
    1. European Platform on Rare Disease Registration. EUROCAT network. Available: https://eu-rd-platform.jrc.ec.europa.eu/eurocat/eurocat-network/eurocat-... [Accessed 2024 Jan 10].
    1. Van der Linde D, Konings EEM, Slager MA, Witsenburg M, Helbing WA, Takkenberg JJM, et al.. Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Coll Cardiol. 2011. Nov 15;58(21):2241‑7. doi: 10.1016/j.jacc.2011.08.025 - DOI - PubMed
    1. Hoffman JIE, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002. Jun 19;39(12):1890‑900. doi: 10.1016/s0735-1097(02)01886-7 - DOI - PubMed