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Multicenter Study
. 2024 Jun;50(6):108309.
doi: 10.1016/j.ejso.2024.108309. Epub 2024 Apr 2.

Impact of neoadjuvant chemotherapy on short-term outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases: A propensity-score matched and coarsened exact matched study

Tijs J Hoogteijling  1 , Mohammad Abu Hilal  2 , Giuseppe Zimmitti  3 , Davit L Aghayan  4 , Andrew G R Wu  5 , Federica Cipriani  6 , Salvatore Gruttadauria  7 , Olivier Scatton  8 , Tran Cong Duy Long  9 , Paulo Herman  10 , Marco V Marino  11 , Vincenzo Mazzaferro  12 , Adrian K H Chiow  13 , Iswanto Sucandy  14 , Arpad Ivanecz  15 , Sung Hoon Choi  16 , Jae Hoon Lee  17 , Mikel Gastaca  18 , Marco Vivarelli  19 , Felice Giuliante  20 , Andrea Ruzzenente  21 , Chee Chien Yong  22 , Mengqiu Yin  23 , Constantino Fondevila  24 , Mikhail Efanov  25 , Zenichi Morise  26 , Fabrizio Di Benedetto  27 , Raffaele Brustia  28 , Raffaele Dalla Valle  29 , Ugo Boggi  30 , David Geller  31 , Andrea Belli  32 , Riccardo Memeo  33 , Alejandro Mejia  34 , James O Park  35 , Fernando Rotellar  36 , Gi Hong Choi  37 , Ricardo Robles-Campos  38 , Xiaoying Wang  39 , Robert P Sutcliffe  40 , Johann Pratschke  41 , Chung-Ngai Tang  42 , Charing C N Chong  43 , Mathieu D'Hondt  44 , Kazuteru Monden  45 , Santiago Lopez-Ben  46 , T Peter Kingham  47 , Alessandro Ferrero  48 , Giuseppe Maria Ettorre  49 , Daniel Cherqui  50 , Xiao Liang  51 , Olivier Soubrane  52 , Go Wakabayashi  53 , Roberto I Troisi  54 , Ho Seong Han  55 , Tan To Cheung  56 , Atsushi Sugioka  57 , Safi Dokmak  58 , Kuo Hsin Chen  59 , Rong Liu  60 , David Fuks  52 , Wanguang Zhang  61 , Luca Aldrighetti  6 , Bjørn Edwin  4 , Brian K P Goh  62 ; International robotic and laparoscopic liver resection study group investigators
Collaborators, Affiliations
Multicenter Study

Impact of neoadjuvant chemotherapy on short-term outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases: A propensity-score matched and coarsened exact matched study

Tijs J Hoogteijling et al. Eur J Surg Oncol. 2024 Jun.

Abstract

Background: In the last three decades, minimally invasive liver resection has been replacing conventional open approach in liver surgery. More recently, developments in neoadjuvant chemotherapy have led to increased multidisciplinary management of colorectal liver metastases with both medical and surgical treatment modalities. However, the impact of neoadjuvant chemotherapy on the surgical outcomes of minimally invasive liver resections remains poorly understood.

Methods: A multicenter, international, database of 4998 minimally invasive minor hepatectomy for colorectal liver metastases was used to compare surgical outcomes in patients who received neoadjuvant chemotherapy with surgery alone. To correct for baseline imbalance, propensity score matching, coarsened exact matching and inverse probability treatment weighting were performed.

Results: 2546 patients met the inclusion criteria. After propensity score matching there were 759 patients in both groups and 383 patients in both groups after coarsened exact matching. Baseline characteristics were equal after both matching strategies. Neoadjuvant chemotherapy was not associated with statistically significant worse surgical outcomes of minimally invasive minor hepatectomy.

Conclusion: Neoadjuvant chemotherapy had no statistically significant impact on short-term surgical outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases.

Keywords: Coarsened exact-matched; Colorectal liver metastases; Difficulty score; Inverse probability treatment weighting; Minimally invasive liver surgery; Minor hepatectomy; Neoadjuvant chemotherapy; Propensity-score matched.

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