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. 2024 Apr 16;24(1):212.
doi: 10.1186/s12872-024-03876-1.

The causal relationship between thoracic aortic aneurysm and immune cells: a mendelian randomization study

Guoli Liu #  1 , Sha Pan #  2 , Hongli Xia  3 , Mincai Li  4 , Ansen Wu  5
Affiliations

The causal relationship between thoracic aortic aneurysm and immune cells: a mendelian randomization study

Guoli Liu et al. BMC Cardiovasc Disord. .

Abstract

One of the pathogenic causes of thoracic aortic aneurysm (TAA), a dangerous vascular condition that can cause aortic rupture, is autoimmune disorders. Currently, immune cell clustering is becoming more and more refined, and the specific immune cell phenotypes involved are yet unknown. Here, we want to clarify the causal link between TAA risk and 731 immune cell traits. There was a Mendelian randomization analysis (MR). We discovered that the presence of TAA led to an increase in CD45 on CD33- HLA-DR- myeloid cells, an increase in CD45 on natural killer cells, and a decrease in FSC-A on granulocytes after applying FDR correction. Our research also revealed a strong correlation between the incidence of TAA and an increase in immune cells with CD3 on CD39+ CD4+, and CD25 on IgD- CD27- phenotypes. Through genetic techniques, our research has shown the intimate relationship between immune cells and TAA, offering direction for future clinical investigations.

Keywords: Genome-wide association study; Immune cells; Mendelian randomization; The causal link; Thoracic aortic aneurysm.

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Conflict of interest statement

The authors declare no competing interests.

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Causal Relationship between TAA and immune cell traits were showed by forest plots. TAA: thoracic aortic aneurysm
Fig. 2
Fig. 2
Causal Relationship between immune cell traits and TAA were showed by forest plots. TAA: thoracic aortic aneurysm
See this image and copyright information in PMC

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