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. 2024 Apr 8:2024:5353528.
doi: 10.1155/2024/5353528. eCollection 2024.

Prevalence of ABO and Rhesus (D) Blood Group and Allelic Frequency at Blood Bank of Nigist Eleni Mohammed Hospital, Ethiopia

Affiliations

Prevalence of ABO and Rhesus (D) Blood Group and Allelic Frequency at Blood Bank of Nigist Eleni Mohammed Hospital, Ethiopia

Fekadu Lendabo et al. Biomed Res Int. .

Abstract

Background: The purpose of this cross-sectional study was to determine the pattern of the ABO and rhesus D (RhD) blood group distribution among voluntary blood donors attending five blood donation centers at Nigist Eleni Mohammed General Hospital in Hossana, Ethiopia.

Methods: A total of 1,120 participants who fulfilled the "who can give blood" criteria of the World Health Organization were selected randomly. Blood samples were collected, transported to the laboratory, and analyzed for ABO and RhD typing. The data was analyzed using descriptive statistics and chi-square correlation analysis.

Results: The study found that the O blood group was the most prevalent (39.0%), followed by A (32.2%), B (22.5%), and AB (6.4%). When considering both the ABO and Rh blood groups together, 92.9% of blood donors were RhD positive, while only 7.1% were RhD negative. The distribution pattern of the ABO blood groups in Gurage Zone, Hadiya Zone, Kembata Zone, and Silte Zone showed that the O blood group was the most prevalent, followed by A, B, and AB, in that order. Conversely, the ABO blood group distribution pattern in Halaba Zone was A > O > B > AB. Civil servants from different occupational statuses were the most dominant voluntary blood donors, accounting for 53.2%, followed by students from different high schools and universities (41.9%), self-employed individuals (4.1%), and others (0.7%). The ABO blood group system had observed allele frequencies significantly different from the expected frequencies (p = 0.007), while the RhD system did not (p = 0.037). Allele frequencies for A, B, and O in the ABO system were 0.3531, 0.2576, and 0.3893, respectively. Observed frequencies for RhD-positive and RhD-negative alleles were 0.9647 and 0.0531, respectively.

Conclusion: This study highlights the regional ABO and RhD blood group variations in Ethiopia, noting disparities from expected ABO allele frequencies, and identifies the O blood group predominance among donors with a high RhD-positive prevalence.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Prevalence of the ABO and RhD blood group phenotype of study participants. The percentages presented represent the proportion of each variable among the total study participants (n = 1,120).
Figure 2
Figure 2
The expected and the observed allele frequencies in the blood group system of study participants. IA, IB, IO, ID, and Id refer to the IA, IB, IO, ID, and Id blood group alleles of ABO and RhD system, respectively.

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References

    1. Lv Y. J., Liang X. F., Wu Y. P. Clinical application of ABO blood typing. Technology and Health Care . 2023;31(4):1375–1383. doi: 10.3233/THC-220659. - DOI - PubMed
    1. Wang C., Tang Y., Zhang P., Xiong L., Chen W., Lv X. Detection and phenotype analysis of a novel Ael blood group allele. Vox Sanguinis . 2024;119(1):74–78. doi: 10.1111/vox.13557. - DOI - PubMed
    1. Yin Q., Ouchari M. Transfusion management of Africans with RHD variants in China. Transfusion Clinique et Biologique . 2023;30(2):287–293. doi: 10.1016/j.tracli.2023.01.003. - DOI - PubMed
    1. Karl J. A., Prall T. M., Bussan H. E., et al. Complete sequencing of a cynomolgus macaque major histocompatibility complex haplotype. Genome Research . 2023;33(3):448–462. doi: 10.1101/gr.277429.122. - DOI - PMC - PubMed
    1. Jajosky R. P., Wu S. C., Zheng L., et al. ABO blood group antigens and differential glycan expression: perspective on the evolution of common human enzyme deficiencies. iScience . 2023;26(1, article 105798) - PMC - PubMed

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