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Meta-Analysis
. 2024 Jun;38(6):2917-2938.
doi: 10.1007/s00464-024-10816-9. Epub 2024 Apr 17.

Management of symptomatic, asymptomatic, and recurrent hiatal hernia: a systematic review and meta-analysis

Nader M Hanna  1 , Sunjay S Kumar  2 , Amelia T Collings  3 , Yagnik K Pandya  4 , James Kurtz  5 , Keshav Kooragayala  6 , Meghan W Barber  7 , Mykola Paranyak  8 , Marina Kurian  9 , Jeffrey Chiu  10 , Ahmed Abou-Setta  11 , Mohammed T Ansari  12 , Bethany J Slater  13 , Geoffrey P Kohn  14   15 , Shaun Daly  16
Affiliations
Meta-Analysis

Management of symptomatic, asymptomatic, and recurrent hiatal hernia: a systematic review and meta-analysis

Nader M Hanna et al. Surg Endosc. 2024 Jun.

Erratum in

Abstract

Background: The surgical management of hiatal hernia remains controversial. We aimed to compare outcomes of mesh versus no mesh and fundoplication versus no fundoplication in symptomatic patients; surgery versus observation in asymptomatic patients; and redo hernia repair versus conversion to Roux-en-Y reconstruction in recurrent hiatal hernia.

Methods: We searched PubMed, Embase, CINAHL, Cochrane Library and the ClinicalTrials.gov databases between 2000 and 2022 for randomized controlled trials (RCTs), observational studies, and case series (asymptomatic and recurrent hernias). Screening was performed by two trained independent reviewers. Pooled analyses were performed on comparative data. Risk of bias was assessed using the Cochrane Risk of Bias tool and Newcastle Ottawa Scale for randomized and non-randomized studies, respectively.

Results: We included 45 studies from 5152 retrieved records. Only six RCTs had low risk of bias. Mesh was associated with a lower recurrence risk (RR = 0.50, 95%CI 0.28, 0.88; I2 = 57%) in observational studies but not RCTs (RR = 0.98, 95%CI 0.47, 2.02; I2 = 34%), and higher total early dysphagia based on five observational studies (RR = 1.44, 95%CI 1.10, 1.89; I2 = 40%) but was not statistically significant in RCTs (RR = 3.00, 95%CI 0.64, 14.16). There was no difference in complications, reintervention, heartburn, reflux, or quality of life. There were no appropriate studies comparing surgery to observation in asymptomatic patients. Fundoplication resulted in higher early dysphagia in both observational studies and RCTs ([RR = 2.08, 95%CI 1.16, 3.76] and [RR = 20.58, 95%CI 1.34, 316.69]) but lower reflux in RCTs (RR = 0.31, 95%CI 0.17, 0.56, I2 = 0%). Conversion to Roux-en-Y was associated with a lower reintervention risk after 30 days compared to redo surgery.

Conclusions: The evidence for optimal management of symptomatic and recurrent hiatal hernia remains controversial, underpinned by studies with a high risk of bias. Shared decision making between surgeon and patient is essential for optimal outcomes.

Keywords: Fundoplication; Hernia; Hiatal; Mesh; Meta-analysis; Systematic review.

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References

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