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Editorial
. 2024 May 7;120(6):565-566.
doi: 10.1093/cvr/cvae064.

Matrix metalloproteinase-3 joins a growing list of proteases that regulate vascular calcification

Cecilia Maria Giachelli  1 , Maristella Donato  1 , Marta Scatena  1
Affiliations
Editorial

Matrix metalloproteinase-3 joins a growing list of proteases that regulate vascular calcification

Cecilia Maria Giachelli et al. Cardiovasc Res. .
No abstract available

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Schematic representation of MMPs-mediated induction of arterial medial calcification. Inducers of vascular calcification (such as elevated phosphate and calcium levels) affect the expression and activity of several proteases. In particular, cathepsins and MMPs are activated and involved in extensive elastolysis and ECM remodelling. Elastin degradation and ECM disorganization then favour ectopic calcification in the medial layer of the arterial wall, which is a risk factor for CV events and mortality. Moreover, MMPs facilitate the initiation and progression of ectopic calcification by directly promoting osteochondrogenic differentiation of VSMCs. Figure created with BioRender.com.
See this image and copyright information in PMC

Comment on

References

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