New insights into the vitamin D/PTH axis in endocrine-driven metabolic bone diseases

doi:10.1007/s12020-024-03784-6

Review

. 2024 Sep;85(3):1007-1019.

doi: 10.1007/s12020-024-03784-6. Epub 2024 Apr 17.

New insights into the vitamin D/PTH axis in endocrine-driven metabolic bone diseases

Luigi di Filippo¹, John P Bilezikian², Ernesto Canalis³, Umberto Terenzi¹, Andrea Giustina⁴

Affiliations

¹ Institute of Endocrine and Metabolic Sciences, San Raffaele Vita Salute University and IRCCS San Raffaele Hospital, Milan, Italy.
² Department of Medicine, Endocrinology Division, Vagelos College of Physicians and Surgeons Columbia University, New York, NY, USA.
³ Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut, USA; Department of Medicine, UConn Health, Farmington, Connecticut, USA; UConn Musculoskeletal Institute, UConn Health, Farmington, CT, USA.
⁴ Institute of Endocrine and Metabolic Sciences, San Raffaele Vita Salute University and IRCCS San Raffaele Hospital, Milan, Italy. giustina.andrea@hsr.it.

PMID: 38632163
DOI: 10.1007/s12020-024-03784-6

Review

New insights into the vitamin D/PTH axis in endocrine-driven metabolic bone diseases

Luigi di Filippo et al. Endocrine. 2024 Sep.

. 2024 Sep;85(3):1007-1019.

doi: 10.1007/s12020-024-03784-6. Epub 2024 Apr 17.

Authors

Luigi di Filippo¹, John P Bilezikian², Ernesto Canalis³, Umberto Terenzi¹, Andrea Giustina⁴

Affiliations

¹ Institute of Endocrine and Metabolic Sciences, San Raffaele Vita Salute University and IRCCS San Raffaele Hospital, Milan, Italy.
² Department of Medicine, Endocrinology Division, Vagelos College of Physicians and Surgeons Columbia University, New York, NY, USA.
³ Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut, USA; Department of Medicine, UConn Health, Farmington, Connecticut, USA; UConn Musculoskeletal Institute, UConn Health, Farmington, CT, USA.
⁴ Institute of Endocrine and Metabolic Sciences, San Raffaele Vita Salute University and IRCCS San Raffaele Hospital, Milan, Italy. giustina.andrea@hsr.it.

PMID: 38632163
DOI: 10.1007/s12020-024-03784-6

Abstract

Background: Endocrine regulation of bone metabolisms is the focus of the "Skeletal Endocrinology" series of meetings.

Aims: To report on the outcome of the discussion on the role of vitamin D/PTH axis in endocrine osteopathies held during the 10^th Skeletal Endocrinology Meeting which took place in Stresa (Italy) in March 2023.

Outcomes: Vitamin D/PTH axis has relevant influence on several outcomes in the general population and in patients affected by endocrinopathies such as hypoparathyroidism and secreting pituitary adenomas.

Conclusions: Assessing the status of the vitamin D/PTH axis and using vitamin D and PTH as therapeutic agents is mandatory in several endocrine-related bone metabolic conditions.

Keywords: Acromegaly; Cushing’s disease; Hypoparathyroidism; Osteoporosis; Skeletal Endocrinology; Vitamin D.

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References

1. E. Canalis, J.P. Bilezikian, A. Angeli, A. Giustina, Perspectives on glucocorticoid-induced osteoporosis. Bone 34(4), 593–598 (2004). https://doi.org/10.1016/j.bone.2003.11.026 - DOI - PubMed
1. G. Mazziotti, J.P. Bilezikian, E. Canalis, D. Cocchi, A. Giustina, New understanding and treatments for osteoporosis. Endocrine 41(1), 58–69 (2012). https://doi.org/10.1007/s12020-011-9570-2 - DOI - PubMed
1. R. Bouillon, C. Marcocci, G. Carmeliet et al. Skeletal and extraskeletal actions of vitamin D: Current evidence and outstanding questions. Endocr. Rev. 40(4), 1109–1151 (2019). https://doi.org/10.1210/er.2018-00126 - DOI - PubMed
1. A. Giustina, R. Bouillon, N. Binkley et al. Controversies in vitamin D: A statement from the third international conference. JBMR 4(12), e10417 (2020). https://doi.org/10.1002/jbm4.10417 - DOI
1. A. Giustina, M. Lazaretti-Castro, A.R. Martineau, R.S. Mason, C.J. Rosen, I. Schoenmakers, A view on vitamin D: a pleiotropic factor?. Nat. Rev. Endocrinol. 20(Jan 4), 202–208 (2024). https://doi.org/10.1038/s41574-023-00942-0 - DOI - PubMed

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[1] E. Canalis, J.P. Bilezikian, A. Angeli, A. Giustina, Perspectives on glucocorticoid-induced osteoporosis. Bone 34(4), 593–598 (2004). https://doi.org/10.1016/j.bone.2003.11.026 - DOI - PubMed

[2] E. Canalis, J.P. Bilezikian, A. Angeli, A. Giustina, Perspectives on glucocorticoid-induced osteoporosis. Bone 34(4), 593–598 (2004). https://doi.org/10.1016/j.bone.2003.11.026 - DOI - PubMed

[3] G. Mazziotti, J.P. Bilezikian, E. Canalis, D. Cocchi, A. Giustina, New understanding and treatments for osteoporosis. Endocrine 41(1), 58–69 (2012). https://doi.org/10.1007/s12020-011-9570-2 - DOI - PubMed

[4] G. Mazziotti, J.P. Bilezikian, E. Canalis, D. Cocchi, A. Giustina, New understanding and treatments for osteoporosis. Endocrine 41(1), 58–69 (2012). https://doi.org/10.1007/s12020-011-9570-2 - DOI - PubMed

[5] R. Bouillon, C. Marcocci, G. Carmeliet et al. Skeletal and extraskeletal actions of vitamin D: Current evidence and outstanding questions. Endocr. Rev. 40(4), 1109–1151 (2019). https://doi.org/10.1210/er.2018-00126 - DOI - PubMed

[6] R. Bouillon, C. Marcocci, G. Carmeliet et al. Skeletal and extraskeletal actions of vitamin D: Current evidence and outstanding questions. Endocr. Rev. 40(4), 1109–1151 (2019). https://doi.org/10.1210/er.2018-00126 - DOI - PubMed

[7] A. Giustina, R. Bouillon, N. Binkley et al. Controversies in vitamin D: A statement from the third international conference. JBMR 4(12), e10417 (2020). https://doi.org/10.1002/jbm4.10417 - DOI

[8] A. Giustina, R. Bouillon, N. Binkley et al. Controversies in vitamin D: A statement from the third international conference. JBMR 4(12), e10417 (2020). https://doi.org/10.1002/jbm4.10417 - DOI

[9] A. Giustina, M. Lazaretti-Castro, A.R. Martineau, R.S. Mason, C.J. Rosen, I. Schoenmakers, A view on vitamin D: a pleiotropic factor?. Nat. Rev. Endocrinol. 20(Jan 4), 202–208 (2024). https://doi.org/10.1038/s41574-023-00942-0 - DOI - PubMed

[10] A. Giustina, M. Lazaretti-Castro, A.R. Martineau, R.S. Mason, C.J. Rosen, I. Schoenmakers, A view on vitamin D: a pleiotropic factor?. Nat. Rev. Endocrinol. 20(Jan 4), 202–208 (2024). https://doi.org/10.1038/s41574-023-00942-0 - DOI - PubMed

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New insights into the vitamin D/PTH axis in endocrine-driven metabolic bone diseases

Affiliations

New insights into the vitamin D/PTH axis in endocrine-driven metabolic bone diseases

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