Efficacy of a new refractive multifocal contact lens for presbyopia

Abstract

This prospective single-arm study aimed to evaluate the clinical efficacy and safety of a refractive multifocal contact lens for the correction of presbyopia in 22 patients. The participants underwent clinical examinations before and 1 week after wearing a refractive multifocal contact lens (OptaCon ZOOM). The primary endpoints were the corrected distance visual acuity (CDVA) and distance-corrected near visual acuity (DCNVA). Defocus curve, contrast sensitivity, and ocular surface disease index (OSDI) were analyzed. A slit-lamp examination was performed for safety analysis. Contact lens comfort and patient satisfaction were assessed using a questionnaire. No significant difference in CDVA was observed before and 1 week after refractive multifocal contact lens use (p = 0.127), whereas DCNVA was significantly improved after 1 week (p < 0.001). The contrast sensitivity was not significantly affected at any spatial frequency under mesopic or photopic conditions. OSDI was significantly increased (p = 0.023). The patient-reported satisfaction scores were 96.2, 91.9, and 85.0 out of 100 at far, intermediate, and near distances, respectively. No significant adverse events were observed. Refractive multifocal contact lenses improved near vision while maintaining distance vision in presbyopic patients, without compromising contrast sensitivity. The study results suggest that OptaCon ZOOM can be considered safe and effective for the correction of presbyopia.

Keywords: Contact lens; Multifocal lens; Presbyopia.

Figure 1

Defocus curve for the mean CDVA values before and after 1 week of multifocal soft contact lens wear. The curve had a U shape with a peak at 0.00D. The mean CDVA at the peak was not significantly different before and after 1 week of lens wear (p-value = 0.317). The result of direct comparison of defocus curve revealed that multifocal soft contact lens wear showed significant improvement of visual outcome for both near and far. It resulted in a significantly improved outcome for near vision particularly at − 2.00D to − 5.00D, corresponding with a 20–50-cm range (p-value < 0.05 in all cases). The result also showed significant improvement in outcome for far vision at + 2.00, + 2.50 and + 3.00D (p-value < 0.05 in all cases).

Figure 2

Diagram illustrating the lens design of OptaCon ZOOM. OptaCon ZOOM is manufactured from silicone hydrogel by cast molding method, with base curve of 8.6 mm and lens diameter of 14.2 mm. OptaCon ZOOM is designed with near vision optimized central 1 mm radius and gradual changes to negative spherical aberration in the periphery, with max vertex refractive power in 4.5 mm zone.

Figure 3

Contrast sensitivity values before and after 1 week of OptaCon ZOOM wear for the correction of presbyopia. The images show binocular contrast sensitivity values under photopic (A) and mesopic (B) conditions.