KRAS G12 mutations as adverse prognostic factors in KMT2A-rearranged acute myeloid leukemia

Shinju Iyoda^#¹, Kenichi Yoshida^#^{2

3}, Kota Shoji^#¹, Nana Ito¹, Miu Tanaka¹, Yasuhito Nannya^{2

4}, Genki Yamato⁵, Shinichi Tsujimoto⁶, Norio Shiba⁶, Yasuhide Hayashi⁷, Yusuke Shiozawa⁸, Yuichi Shiraishi⁹, Kenichi Chiba⁹, Ai Okada⁹, Hiroko Tanaka¹⁰, Satoru Miyano¹⁰, Yuhki Koga¹¹, Hiroaki Goto¹², Hiroshi Moritake¹³, Kiminori Terui¹⁴, Etsuro Ito¹⁴, Nobutaka Kiyokawa¹⁵, Daisuke Tomizawa¹⁶, Takashi Taga¹⁷, Akio Tawa¹⁸, Junko Takita¹⁹, Momoko Nishikori¹, Souichi Adachi^{1

20}, Seishi Ogawa², Hidemasa Matsuo^{21

22}

Affiliations

¹ Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
² Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
³ Division of Cancer Evolution, National Cancer Center Research Institute, Tokyo, Japan.
⁴ Division of Hematopoietic Disease Control, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
⁵ Department of Pediatrics, Gunma University Graduate School of Medicine, Maebashi, Japan.
⁶ Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
⁷ Institute of Physiology and Medicine, Jobu University, Takasaki, Japan.
⁸ Laboratory of Molecular Analysis, Nippon Medical School, Tokyo, Japan.
⁹ Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Tokyo, Japan.
¹⁰ Department of Integrated Analytics, M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.
¹¹ Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
¹² Division of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan.
¹³ Division of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
¹⁴ Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
¹⁵ Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.
¹⁶ Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
¹⁷ Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan.
¹⁸ Department of Pediatrics, Higashiosaka Aramoto Heiwa Clinic, Higashiosaka, Japan.
¹⁹ Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
²⁰ Shiga General Hospital, Moriyama, Japan.
²¹ Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. matsuo@kuhp.kyoto-u.ac.jp.
²² Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan. matsuo@kuhp.kyoto-u.ac.jp.

^# Contributed equally.

PMID: 38632314
DOI: 10.1038/s41375-024-02244-4

KRAS G12 mutations as adverse prognostic factors in KMT2A-rearranged acute myeloid leukemia

Shinju Iyoda et al. Leukemia. 2024 Jul.

. 2024 Jul;38(7):1609-1612.

doi: 10.1038/s41375-024-02244-4. Epub 2024 Apr 18.

Authors

Affiliations

¹ Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
² Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
³ Division of Cancer Evolution, National Cancer Center Research Institute, Tokyo, Japan.
⁴ Division of Hematopoietic Disease Control, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
⁵ Department of Pediatrics, Gunma University Graduate School of Medicine, Maebashi, Japan.
⁶ Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
⁷ Institute of Physiology and Medicine, Jobu University, Takasaki, Japan.
⁸ Laboratory of Molecular Analysis, Nippon Medical School, Tokyo, Japan.
⁹ Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Tokyo, Japan.
¹⁰ Department of Integrated Analytics, M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.
¹¹ Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
¹² Division of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan.
¹³ Division of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
¹⁴ Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
¹⁵ Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.
¹⁶ Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
¹⁷ Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan.
¹⁸ Department of Pediatrics, Higashiosaka Aramoto Heiwa Clinic, Higashiosaka, Japan.
¹⁹ Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
²⁰ Shiga General Hospital, Moriyama, Japan.
²¹ Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. matsuo@kuhp.kyoto-u.ac.jp.
²² Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan. matsuo@kuhp.kyoto-u.ac.jp.

^# Contributed equally.

PMID: 38632314
DOI: 10.1038/s41375-024-02244-4

No abstract available

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References

1. Khwaja A, Bjorkholm M, Gale RE, Levine RL, Jordan CT, Ehninger G, et al. Acute myeloid leukaemia. Nat Rev Dis Prim. 2016;2:16010. - DOI - PubMed
1. Creutzig U, van den Heuvel-Eibrink MM, Gibson B, Dworzak MN, Adachi S, de Bont E, et al. Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel. Blood. 2012;120:3187–205. - DOI - PubMed
1. Bolouri H, Farrar JE, Triche T Jr, Ries RE, Lim EL, Alonzo TA, et al. The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions. Nat Med. 2018;24:103–12. - DOI - PubMed
1. Meyer C, Larghero P, Almeida Lopes B, Burmeister T, Gröger D, Sutton R, et al. The KMT2A recombinome of acute leukemias in 2023. Leukemia. 2023;37:988–1005. - DOI - PubMed - PMC
1. Balgobind BV, Raimondi SC, Harbott J, Zimmermann M, Alonzo TA, Auvrignon A, et al. Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study. Blood. 2009;114:2489–96. - DOI - PubMed - PMC

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KRAS G12 mutations as adverse prognostic factors in KMT2A-rearranged acute myeloid leukemia

Affiliations

KRAS G12 mutations as adverse prognostic factors in KMT2A-rearranged acute myeloid leukemia

Authors

Affiliations

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous