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. 2024 Apr 17;19(1):241.
doi: 10.1186/s13019-024-02691-1.

Relationship between pan-immune- inflammation value and in major cardiovascular and cerebrovascular events in stable coronary artery disease patients undergoing on-pump coronary artery bypass graft surgery

Ahmet Dolapoglu  1 , Eyup Avci  2
Affiliations

Relationship between pan-immune- inflammation value and in major cardiovascular and cerebrovascular events in stable coronary artery disease patients undergoing on-pump coronary artery bypass graft surgery

Ahmet Dolapoglu et al. J Cardiothorac Surg. .

Abstract

Background: In this study, we aimed to evaluate the association of pan-immune-inflammation value (PIV) with major cardiovascular and cerebrovascular events (MACCE) in stable coronary artery disease patients undergoing on-pump coronary artery bypass graft (CABG) surgery.

Methods: We retrospectively analyzed data from 527 patients who underwent on-pump CABG surgery for stable coronary artery disease between June 2015 and December 2020. Patients were categorized into two groups based on MACCE development. PIV levels were calculated from blood samples taken on admission. PIV was calculated as [neutrophil count (×103/µL)×platelet count (×103/µL))×monocyte count (×103/µL)]/lymphocyte count (×103/µL). The primary endpoint was long-term major cardiovascular and cerebrovascular events (MACCE) at a median follow-up of 4.6 years.

Results: Of the included patients, 103 (19.5%) developed MACCE. PIV was higher in patients with MACCE compared to those without (470.8 [295.3-606.8] vs. 269.8 [184.3-386.4], p < 0.001). Multivariate analysis showed a significant positive association between PIV and MACCE (HR: 1.326, 95%CI:1.212-1452, p < 0.001). The cut-off value for the PIV in the estimation of MACCE was 368.28 ( AUC: 0.726 with 69% sensitivity, 71% specificity, p < 0.001).

Conclusion: This study shows a significant link between high PIV levels and MACCE in stable coronary artery disease patients undergoing on-pump CABG surgery. Our findings suggest that PIV may be a valuable, routinely available, and inexpensive marker for identifying patients at increased risk of MACCE.

Keywords: Coronary artery bypass graft; Major cardiovascular and cerebrovascular events; Pan-immune-inflammation value; Stable coronary artery disease.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The long-term predictors of major cardiovascular and cerebrovascular events (MACCE). COPD; chronic obstructive pulmonary disease, PAD; peripheral artery disease, DM; diabetes mellitus, IABP; intra-aortic balloon pump, LVEF; left ventricular ejection fraction, HGB; haemoglobin, PIV; Pan-Immune-Inflammation Value
Fig. 2
Fig. 2
Receiver operating characteristic (ROC) curves for the neutrophil to lymphocyte ratio( NLR), monocyte, platelet, systemic-immunoinflammatory index (SII ), and Pan-Immune-Inflammation Value (PIV) for predicting major cardiovascular and cerebrovascular events (MACCE).
Fig. 3
Fig. 3
Receiver operating characteristic (ROC) curves for the multivariable model, multivariable model plus Pan-Immune-Inflammation Value (PIV) for predicting major cardiovascular and cerebrovascular events (MACCE).
Fig. 4
Fig. 4
Kaplan–Meier estimate of the cumulative incidence of the major cardiovascular and cerebrovascular events (MACCE ) according to Pan-Immune-Inflammation Value (PIV) before matching
Fig. 5
Fig. 5
Major cardiovascular and cerebrovascular events (MACCE ) in matching group
Fig. 6
Fig. 6
Kaplan–Meier estimate of the cumulative incidence of the major cardiovascular and cerebrovascular events (MACCE ) according to Pan-Immune-Inflammation Value (PIV) after matching
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