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. 2024 Apr 13:17:1701-1713.
doi: 10.2147/DMSO.S454711. eCollection 2024.

Fractional Excretion of Urate is Positively Associated with Type 2 Diabetes in HUA Patients: A Cross-Sectional Study

Bo Huang #  1 , Xin Li #  1 , Xinxin Zhang  1 , Shiwei Li  1 , Yue Liu  1 , Mengjuan Zhang  1 , Jingqiu Cui  1
Affiliations

Fractional Excretion of Urate is Positively Associated with Type 2 Diabetes in HUA Patients: A Cross-Sectional Study

Bo Huang et al. Diabetes Metab Syndr Obes. .

Abstract

Purpose: People with hyperuricemia (HUA) are often related to metabolic disorders such as diabetes, metabolic syndrome (MetS), and obesity. However, the correlation between excretion of uric acid and these diseases is unclear. Our study aimed to explore the relationship between uric acid excretion and type 2 diabetes (T2D).

Methods: A total of 228 HUA patients from Tianjin Medical University General Hospital from 2022 to 2023 were included in this study. We collected demographic, biochemical, and anthropometric data on each subject. Urine uric acid excretion (UUAE) was calculated enzymatically from a single urine collection that lasted 24 hours. And fractional excretion of uric acid (FEUA) was calculated from serum uric acid and creatinine and uric acid and creatinine. Binary logistic regression modeling assessed the association between uric acid excretion and T2D.

Results: Of the 228 subjects, 13.4% had T2D and 48.7% had obesity. The obesity group had a lower FEUA (p<0.05) and a higher UUAE compared to the control group (p<0.05). And FEUA had a stronger correlation with the risk of T2D (p<0.001). Also, there was a negative association between BMI and FEUA and a positive link between BMI and UUAE in the outpatients.

Conclusion: Increased FEUA levels were significantly associated with T2D in HUA patients. Therefore, routine calculating of FEUA is essential for proper diagnosis and appropriate treatment T2D of in HUA patients.

Keywords: Type 2 diabetes; fractional excretion of urate; hyperuricemia; obesity; urine uric acid excretion.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

None
Graphical abstract
Figure 1
Figure 1
Flowchart of the cross-sectional study.
Figure 2
Figure 2
Comparison of FEUA levels between the patients with and without T2D and obesity.
Figure 3
Figure 3
(A) Prevalence of obesity stratified by UUAE quartile in HUA. (B) Comparison of UA levels stratified by FEUA quartile in HUA.
See this image and copyright information in PMC

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