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Editorial
. 2024 Oct 1;109(10):3094-3096.
doi: 10.3324/haematol.2024.285257.

'One way, or another, I'm gonna find ya': miR-221-3p finds its targets via small extracellular vesicles

Jonathan Tak-Sum Chow  1 , Leonardo Salmena  1
Affiliations
Editorial

'One way, or another, I'm gonna find ya': miR-221-3p finds its targets via small extracellular vesicles

Jonathan Tak-Sum Chow et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Small extracellular vesicles miR-221-3p promotes leukemogenesis through autocrine and paracrine signaling in the bone marrow niche. Acute myelod leukemia (AML)-derived small extracellular vesicles (sEV) containing miR-221-3p can support AML cell growth in an autocrine manner by promoting cell cycle progression and inhibiting apoptosis, in part through inhibiting Gbp2 and regulation of PI3K/Akt signaling. Simultaneously, sEV miR-221-3p can suppress normal hematopoiesis by suppressing hemtopoietic stem and progenitor cell (HSPC) differentiation in a paracrine manner. These concurrent autocrine and paracrine functions of sEV miR-221-3p consist of a “two-pronged impact” on the bone marrow niche that ultimately favors leukemogenesis.
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