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Review
. 2024 Apr 18;73(Suppl 1):S185-S198.
doi: 10.33549/physiolres.935265. Epub 2024 Apr 18.

Epitranscriptomic Regulations in the Heart

D Benak  1 , F Kolar, M Hlavackova
Affiliations
Review

Epitranscriptomic Regulations in the Heart

D Benak et al. Physiol Res. .

Abstract

RNA modifications affect key stages of the RNA life cycle, including splicing, export, decay, and translation. Epitranscriptomic regulations therefore significantly influence cellular physiology and pathophysiology. Here, we selected some of the most abundant modifications and reviewed their roles in the heart and in cardiovascular diseases: N6-methyladenosine (m6A), N6,2'-O-dimethyladenosine (m6Am), N1-methyladenosine (m1A), pseudouridine (?), 5 methylcytidine (m5C), and inosine (I). Dysregulation of epitranscriptomic machinery affecting these modifications vastly changes the cardiac phenotype and is linked with many cardiovascular diseases such as myocardial infarction, cardiomyopathies, or heart failure. Thus, a deeper understanding of these epitranscriptomic changes and their regulatory mechanisms can enhance our knowledge of the molecular underpinnings of prevalent cardiac diseases, potentially paving the way for novel therapeutic strategies. Keywords: Epitranscriptomics, RNA modifications, Epigenetics, m6A, RNA, Heart.

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Conflict of interest statement

Conflict of Interest: There is no conflict of interest.

Figures

Fig. 1
Fig. 1
Basic overview of epigenetic modifications. Created with BioRender.com
Fig. 2
Fig. 2
Common RNA modifications. Created with BioRender.com
Fig. 3
Fig. 3
Role of RNA modifications in the heart. Created with BioRender.com
See this image and copyright information in PMC

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