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. 2024 Apr 18;19(4):e0295986.
doi: 10.1371/journal.pone.0295986. eCollection 2024.

Potassium affects the association between dietary intake of vitamin C and NAFLD among adults in the United States

Xu-Hua Liu  1   2 , Hao-Kai Chen  1   2 , Jing Luo  1   2 , Xiang-Ping He  1   3 , Wan-Lin Zhang  1   4 , Yue Chen  1   5 , Xiu-Juan Li  1   2 , Qi-Wen Lan  1   6 , Xiao-Man Ma  1   2 , Xu-Guang Guo  1   2   7
Affiliations

Potassium affects the association between dietary intake of vitamin C and NAFLD among adults in the United States

Xu-Hua Liu et al. PLoS One. .

Abstract

Introduction: Although the association between nonalcoholic fatty liver disease (NAFLD) and vitamin C has been well studied, the effects of dietary potassium intake on this relationship are still unclear. Thus, this study aimed to determine the effects of dietary potassium intake on the association between vitamin C and NAFLD.

Methods: We performed a cross-sectional learn about with 9443 contributors the usage of 2007-2018 NHANES data. Multiple logistic regression evaluation has been utilized to check out the affiliation of dietary vitamin C intake with NAFLD and advanced hepatic fibrosis (AHF). Subsequently, we plotted a smoothed match curve to visualize the association. Especially, the analysis of AHF was conducted among the NAFLD population. In addition, stratified evaluation used to be developed primarily based on demographic variables to verify the steadiness of the results. Effect amendment by way of dietary potassium intake used to be assessed via interplay checks between vitamin C and NAFLD in the multivariable linear regression.

Results: In this cross-sectional study, we found that vitamin C was negatively related to NAFLD and AHF. The relationship between vitamin C and NAFLD was different in the low, middle and high potassium intake groups. Furthermore, potassium intake significantly modified the negative relationship between vitamin C and NAFLD in most of the models.

Conclusion: Our research showed that potassium and vitamin C have an interactive effect in reducing NAFLD, which may have great importance for clinical medication.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. A flowchart showing the selection of study participants.
Fig 2
Fig 2. Smoothing curve fitting plot.
(A) The association between dietary vitamin C intake and NAFLD. (B) The association between dietary vitamin C intake and AHF.
See this image and copyright information in PMC

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