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Review
. 2024 Apr 18;189(3):34.
doi: 10.1007/s11046-024-00837-2.

Metagenomic Next-Generation Sequencing Contributes to the Early Diagnosis of Mixed Infections in Central Nervous System

Li Lin #  1   2 , Junyue Fang #  1   3 , Jiahao Li #  1   2 , Ying Tang  1   2 , Tengteng Xin  1   2 , Nengtai Ouyang  1   3 , Wenying Cai  1   2 , Lisi Xie  4 , Sha Lu  5   6 , Junmin Zhang  7   8
Affiliations
Review

Metagenomic Next-Generation Sequencing Contributes to the Early Diagnosis of Mixed Infections in Central Nervous System

Li Lin et al. Mycopathologia. .

Abstract

Central nervous system (CNS) infections represent a challenge due to the complexities associated with their diagnosis and treatment, resulting in a high incidence rate and mortality. Here, we presented a case of CNS mixed infection involving Candida and human cytomegalovirus (HCMV), successfully diagnosed through macrogenomic next-generation sequencing (mNGS) in China. A comprehensive review and discussion of previously reported cases were also provided. Our study emphasizes the critical role of early pathogen identification facilitated by mNGS, underscoring its significance. Notably, the integration of mNGS with traditional methods significantly enhances the diagnostic accuracy of CNS infections. This integrated approach has the potential to provide valuable insights for clinical practice, facilitating early diagnosis, allowing for treatment adjustments, and ultimately, improving the prognosis for patients with CNS infections.

Keywords: Candida; Central nervous system; Fungus; Human cytomegalovirus; Metagenomic next-generation sequencing.

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