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Review
. 2025;22(1):e170424229033.
doi: 10.2174/0115701638292980240407135246.

Harnessing the Therapeutic Potential of Dillenia indica: An Overview of Recent Dosage Form Developments

Aditya Bora  1 , Pallab Kalita  1 , Parimita Kalita  2 , Rudra Prasad Adhikari  1 , Aaditya Das  1 , Rizuwan Zaheer  1 , Mustaf Alam Laskar  1 , Kalyani Pathak  3
Affiliations
Review

Harnessing the Therapeutic Potential of Dillenia indica: An Overview of Recent Dosage Form Developments

Aditya Bora et al. Curr Drug Discov Technol. 2025.

Abstract

Dillenia indica, commonly known as Elephant Apple, is a significant medicinal plant found in Assam, North-East India. This evergreen shrub or small to medium-sized tree possesses not only tasty components but also a plethora of beneficial therapeutic characteristics. This review article aims to explore the potential use of Dillenia indica in the treatment of diabetes and other diseases, as well as discuss various patents associated with this plant. The study focuses on identifying different formulations derived from various parts of Dillenia indica. These formulations encompass a range of dosage forms, including mucoadhesive buccal dosage forms, buccal patches, microbeads, emulgel, and mucoadhesive nasal gel. Each of these dosage forms offers unique advantages and applications. Mucoadhesive buccal dosage forms are designed to adhere to the oral mucosa, allowing for controlled drug release and enhanced absorption. Buccal patches provide a convenient and localized delivery system for specific therapeutic agents. Microbeads offer a versatile approach for encapsulating drugs and facilitating their controlled release. Emulgels combine the benefits of both emulsions and gels, providing improved drug delivery and stability. Mucoadhesive nasal gels offer a non-invasive route for drug administration, allowing for rapid absorption through the nasal mucosa. By exploring these different formulations, researchers aim to harness the therapeutic potential of Dillenia indica in a variety of diseases, including diabetes. The study also highlights the importance of patents associated with Dillenia indica, indicating the growing interest in its medicinal properties and potential commercial applications. Dillenia indica holds promise as a valuable medicinal plant, with its diverse therapeutic characteristics and tasty components. The study discussed various formulations derived from different parts of the plant, showcasing their potential applications in the treatment of diseases. Further research and development in this field may lead to the discovery of novel treatments and contribute to the advancement of pharmaceutical science.

Keywords: Mucoadhesive; emugeland patents; medicinal herbs.; microbeads; nasal mucosa; patches.

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References

    1. Barua C.C.; Yasmin N.; Buragohain L.; A review update on Dillenia indica, its morphology, phytochemistry and pharmacological activity with reference to its anticancer activity. MOJ Bioequivalence and Bioavailability 2018,5(5),244-254 - DOI
    1. Rai H.; Sajwan S.U.A.; An overview of Dillenia indica and their properties. Pharma Innovation Journal 2020,9(6),41-44
    1. Metia P.K.; Bandyopadhyay A.K.; In vitro and in vivo evaluation of a novel mucoadhesive buccal oxytocin tablet prepared with Dillenia indica fruit mucilage. Pharmazie 2008,63(4),270-274 - PubMed
    1. De D.; Chowdhury P.; Panda S.K.; Ghosh U.; Leaf Extract and Active Fractions of Dillenia pentagyna Roxb. Reduce In Vitro Human Cancer Cell Migration Via NF-κB Pathway. Integr Cancer Ther 2022,21 - DOI - PubMed
    1. Lima C.C.; Lemos R.P.L.; Conserva L.M.; Dilleniaceae family: an overview of its ethnomedicinal uses, biological and phytochemical profile. J Pharmacogn Phytochem 2014,3,181-204