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Review
. 2024 Apr 4:15:1388747.
doi: 10.3389/fphar.2024.1388747. eCollection 2024.

A comprehensive review of Siraitia grosvenorii (Swingle) C. Jeffrey: chemical composition, pharmacology, toxicology, status of resources development, and applications

Huaxue Huang #  1   2   3   4 , Zhi Peng #  3   4 , Shuang Zhan  3   4 , Wei Li  3   4 , Dai Liu  3   4 , Sirui Huang  3   4 , Yizhun Zhu #  1 , Wei Wang #  1   2
Affiliations
Review

A comprehensive review of Siraitia grosvenorii (Swingle) C. Jeffrey: chemical composition, pharmacology, toxicology, status of resources development, and applications

Huaxue Huang et al. Front Pharmacol. .

Abstract

Siraitia grosvenorii (Swingle) C. Jeffrey (S. grosvenorii), a perennial indigenous liana from the Cucurbitaceae family, has historically played a significant role in southern China's traditional remedies for various ailments. Its dual classification by the Chinese Ministry of Health for both medicinal and food utility underscores its has the potential of versatile applications. Recent research has shed light on the chemical composition, pharmacological effects, and toxicity of S. grosvenorii. Its active ingredients include triterpenoids, flavonoids, amino acids, volatile oils, polysaccharides, minerals, vitamins, and other microconstituents. Apart from being a natural sweetener, S. grosvenorii has been found to have numerous pharmacological effects, including alleviating cough and phlegm, preventing dental caries, exerting anti-inflammatory and anti-allergic effects, anti-aging and anti-oxidative, hypoglycemic, lipid-lowering, anti-depression, anti-fatigue, anti-schizophrenic, anti-Parkinson, anti-fibrotic, and anti-tumor activities. Despite its versatile potential, there is still a lack of systematic research on S. grosvenorii to date. This paper aims to address this gap by providing an overview of the main active components, pharmacological efficacy, toxicity, current status of development and application, development dilemmas, and strategies for intensive exploitation and utilization of S. grosvenorii. This paper aims to serve as a guide for researchers and practitioners committed to exploiting the biological resources of S. grosvenorii and further exploring its interdisciplinary potential.

Keywords: Siraitia grosvenorii; chemical compounds; mogrosides; pharmacological effects; resource development status; toxicological effects.

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Conflict of interest statement

Authors HH, ZP, SZ, WL, DL, SH were employed by Hunan Huacheng Biotech, Inc. Authors HH, ZP, SZ, WL, DL, SH were employed by Hunan Natural Sweetener Engineering Technology Research Center. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
(A) The flowers, stems, and leaves of S. grosvenorii. (B) Fresh fruit of S. grosvenorii. (C) Dry fruit of S. grosvenorii.
FIGURE 2
FIGURE 2
The structures of triterpenoids (compounds 1–78) from S. grosvenorii.
FIGURE 3
FIGURE 3
The structures of triterpenoids (compounds 79–107) from S. grosvenorii.
FIGURE 4
FIGURE 4
The structures of triterpenoids (compounds 108–131) from S. grosvenorii.
FIGURE 5
FIGURE 5
The structures of flavonoids from S. grosvenorii.
FIGURE 6
FIGURE 6
The structures of amino acids from S. grosvenorii.
FIGURE 7
FIGURE 7
The structures of volatile oils from S. grosvenorii.
See this image and copyright information in PMC

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