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. 2024 Apr;29(16):2400188.
doi: 10.2807/1560-7917.ES.2024.29.16.2400188.

Emergence of OXA-48-producing Klebsiella pneumoniae in Lithuania, 2023: a multi-cluster, multi-hospital outbreak

Paulius Greičius  1 , Marius Linkevicius  2 , Jelena Razmuk  1 , Jekaterina Sinotova  1 , Erik Alm  2 , Olov Svartström  2 , Valeria Bortolaia  3 , Eglė Kudirkienė  3 , Louise Roer  3 , Rene S Hendriksen  4 , Gabija Tamoliūnaitė  1 , Daniel Palm  2 , Dominique L Monnet  2 , Anke Kohlenberg  2 , Algirdas Griškevičius  1
Affiliations

Emergence of OXA-48-producing Klebsiella pneumoniae in Lithuania, 2023: a multi-cluster, multi-hospital outbreak

Paulius Greičius et al. Euro Surveill. 2024 Apr.

Abstract

In 2023, an increase of OXA-48-producing Klebsiella pneumoniae was noticed by the Lithuanian National Public Health Surveillance Laboratory. Whole genome sequencing (WGS) of 106 OXA-48-producing K. pneumoniae isolates revealed three distinct clusters of carbapenemase-producing K. pneumoniae high-risk clones, including sequence type (ST) 45 (n = 35 isolates), ST392 (n = 32) and ST395 (n = 28), involving six, six and nine hospitals in different regions, respectively. These results enabled targeted investigation and control, and underscore the value of national WGS-based surveillance for antimicrobial resistance.

Keywords: Klebsiella pneumoniae; OXA-48; carbapenem-resistant Enterobacterales; carbapenemase; surveillance; whole genome sequencing.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Clusters of OXA-48-producing Klebsiella pneumoniae isolates by hospital, Lithuania, 2022–2023 (n = 106 isolates)
Figure 2
Figure 2
Epidemic curves for the three major Klebsiella pneumoniae clusters by hospital, Lithuania, 2022–2023 (n = 95 cases)
Figure 3
Figure 3
Meropenem minimal inhibitory concentration values for Klebsiella pneumoniae isolates from the three major clusters, Lithuania, 2022–2023 (n = 95 isolates)
See this image and copyright information in PMC

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