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. 2024 Apr 19;28(1):33-44.
doi: 10.34763/jmotherandchild.20242801.d-24-00010. eCollection 2024 Feb 1.

Cerebral rScO2 Measured by Near-Infrared Spectroscopy (NIRS) During Therapeutic Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy: A Systematic Review

Sergio Agudelo-Pérez  1 , Gloria Troncoso  2 , Alejandra Roa  3 , Ana Gabriela Ariza  3 , Georgina Doumat  3 , Natalia M Reinoso  3 , Daniel Botero-Rosas  4
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Cerebral rScO2 Measured by Near-Infrared Spectroscopy (NIRS) During Therapeutic Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy: A Systematic Review

Sergio Agudelo-Pérez et al. J Mother Child. .

Abstract

Introduction: Perinatal asphyxia, a leading cause of neonatal mortality and neurological sequelae, necessitates early detection of pathophysiological neurologic changes during hypoxic-ischaemic encephalopathy (HIE). This study aimed to review published data on rScO2 monitoring during hypothermia treatment in neonates with perinatal asphyxia to predict short- and long-term neurological injury.

Methods: A systematic review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Study identification was performed through a search between November and December 2021 in the electronic databases PubMed, Embase, Lilacs, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials (CENTRAL). The main outcome was short-term (Changes in brain magnetic resonating imaging) and long-term (In neurodevelopment) neurological injury. The study protocol was registered in PROSPERO (International Prospective Register of Systematic Reviews) with CRD42023395438.

Results: 380 articles were collected from databases in the initial search. Finally, 15 articles were selected for extraction and analysis of the information. An increase in rScO2 measured by NIRS (Near-infrared spectroscopy) at different moments of treatment predicts neurological injury. However, there exists a wide variability in the methods and outcomes of the studies.

Conclusion: High rScO2 values were found to predict negative outcomes, with substantial discord among studies. NIRS is proposed as a real-time bedside tool for predicting brain injury in neonates with moderate to severe HIE.

Keywords: Asphyxia; Hypothermia Therapeutic; Hypoxic-ischemic encephalopathy; Newborn; Spectroscopy Near-Infrared.

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Figures

Figure 1.
Figure 1.
Flowchart of the study.
Figure 2.
Figure 2.
Quality of the selected articles, using STROBE: cohort studies.
See this image and copyright information in PMC

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