Clonal hematopoiesis of indeterminate potential and risk of hepatocellular carcinoma: New kids on the block

Yi-Te Lee¹, Hsian-Rong Tseng^{2

3}, Ju Dong Yang^{1

4

5}

Affiliations

¹ Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
² Department of Molecular and Medical Pharmacology, California NanoSystems Institute, Crump Institute for Molecular Imaging, University of California, Los Angeles, Los Angeles, California, USA.
³ Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA.
⁴ Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, California, USA.
⁵ Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

PMID: 38640021
PMCID: PMC12068683
DOI: 10.1097/HEP.0000000000000898

Editorial

Clonal hematopoiesis of indeterminate potential and risk of hepatocellular carcinoma: New kids on the block

Yi-Te Lee et al. Hepatology. 2024.

. 2024 Oct 1;80(4):763-765.

doi: 10.1097/HEP.0000000000000898. Epub 2024 Apr 19.

Authors

Yi-Te Lee¹, Hsian-Rong Tseng^{2

3}, Ju Dong Yang^{1

4

5}

Affiliations

¹ Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
² Department of Molecular and Medical Pharmacology, California NanoSystems Institute, Crump Institute for Molecular Imaging, University of California, Los Angeles, Los Angeles, California, USA.
³ Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA.
⁴ Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, California, USA.
⁵ Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

PMID: 38640021
PMCID: PMC12068683
DOI: 10.1097/HEP.0000000000000898

No abstract available

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Conflict of interest statement

Conflicts of interest:

Hsian-Rong Tseng is employed by and owns stock in Eximus Diagnostics. He owns stock in CytoLumina and Pulsar. Ju Dong Yang consults for AstraZeneca, Eisai, Exact, Excelixis, Fujifilm, Gilead, and Merck. The remaining author has no conflicts to report.

Comment on

Impact of clonal hematopoiesis of indeterminate potential on hepatocellular carcinoma in individuals with steatotic liver disease.
Marchetti A, Pelusi S, Marella A, Malvestiti F, Ricchiuti A, Ronzoni L, Lionetti M, Moretti V, Bugianesi E, Miele L, Vespasiani-Gentilucci U, Dongiovanni P, Federico A, Soardo G, D'Ambrosio R, McCain MV, Reeves HL, La Mura V, Prati D, Bolli N, Valenti L; EPIDEMIC Study Investigators. Marchetti A, et al. Hepatology. 2024 Oct 1;80(4):816-827. doi: 10.1097/HEP.0000000000000839. Epub 2024 Mar 11. Hepatology. 2024. PMID: 38470216 Free PMC article.

References

1. Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR. A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nature reviews. Gastroenterology & hepatology 2019;16:589–604. - PMC - PubMed
1. Lee YT, Wang JJ, Luu M, Tseng HR, Rich NE, Lu SC, Nissen NN, et al. State-Level HCC Incidence and Association With Obesity and Physical Activity in the United States. Hepatology 2021;74:1384–1394. - PubMed
1. Karim MA, Singal AG, Kum HC, Lee YT, Park S, Rich NE, Noureddin M, et al. Clinical Characteristics and Outcomes of Nonalcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in the United States. Clin Gastroenterol Hepatol 2023;21:670–680.e618. - PMC - PubMed
1. Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 2016;64:73–84. - PubMed
1. Estes C, Razavi H, Loomba R, Younossi Z, Sanyal AJ. Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease. Hepatology (Baltimore, Md.) 2018;67:123–133. - PMC - PubMed

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Clonal hematopoiesis of indeterminate potential and risk of hepatocellular carcinoma: New kids on the block

Affiliations

Clonal hematopoiesis of indeterminate potential and risk of hepatocellular carcinoma: New kids on the block

Authors

Affiliations

Conflict of interest statement

Comment on

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical