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Meta-Analysis
. 2024 Apr 19;103(16):e37020.
doi: 10.1097/MD.0000000000037020.

Comparative study between remifentanil (or fentanyl) and dexmedetomidine for the analgesia of rhinoplasty: A meta-analysis of randomized controlled trials

Jiao Yang  1 , Xuejun Wu, Jinfeng Nie
Affiliations
Meta-Analysis

Comparative study between remifentanil (or fentanyl) and dexmedetomidine for the analgesia of rhinoplasty: A meta-analysis of randomized controlled trials

Jiao Yang et al. Medicine (Baltimore). .

Abstract

Background: Remifentanil (or fentanyl) and dexmedetomidine may have some potential to improve the analgesia of rhinoplasty, and this meta-analysis aims to compare their efficacy for the analgesia of rhinoplasty.

Methods: PubMed, Embase, Web of Science, EBSCO, and Cochrane Library databases were systematically searched, and we included randomized controlled trials (RCTs) assessing the analgesic effect of remifentanil (or fentanyl) versus dexmedetomidine for rhinoplasty.

Results: Four RCTs were finally included in the meta-analysis. In patients undergoing rhinoplasty, remifentanil (or fentanyl) infusion and dexmedetomidine infusion resulted in similar good patient satisfaction (odd ratio [OR] = 2.71; 95% confidence interval [CI] = 0.63 to 11.64; P = .18), good surgeon satisfaction (OR = 1.68; 95% CI = 0.02 to 181.40; P = .83), extubation time (mean difference [MD] = 7.56; 95% CI = -11.00 to 26.12; P = .42), recovery time (MD = -2.25; 95% CI = -23.41 to 18.91; P = .83), additional analgesic requirement (OR = 0.16; 95% CI = 0 to 8.65; P = .37) and adverse events (OR = 8.50; 95% CI = 0.47 to 153.30; P = .15).

Conclusions: Remifentanil (or fentanyl) and dexmedetomidine may have comparable analgesia for patients undergoing rhinoplasty.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
The quality of evidence for each outcome by GRADE recommendations.
Figure 2.
Figure 2.
Flow diagram of study searching and selection process.
Figure 3.
Figure 3.
Risk of bias assessment. (A) Authors’ judgments about each risk of bias item for each included study. (B) Authors’ judgments about each risk of bias item presented as percentages across all included studies.
Figure 4.
Figure 4.
Forest plot for the meta-analysis of good patient satisfaction.
Figure 5.
Figure 5.
Forest plot for the meta-analysis of good surgeon satisfaction.
Figure 6.
Figure 6.
Forest plot for the meta-analysis of extubation time.
Figure 7.
Figure 7.
Forest plot for the meta-analysis of recovery time.
Figure 8.
Figure 8.
Forest plot for the meta-analysis of additional analgesic requirement.
Figure 9.
Figure 9.
Forest plot for the meta-analysis of adverse events.
See this image and copyright information in PMC

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