Who am I with my Lewy bodies? The insula as a core region of the self-concept networks

Abstract

Background: Dementia with Lewy bodies (DLB) is characterized by insular atrophy, which occurs at the early stage of the disease. Damage to the insula has been associated with disorders reflecting impairments of the most fundamental components of the self, such as anosognosia, which is a frequently reported symptom in patients with Lewy bodies (LB). The purpose of this study was to investigate modifications of the self-concept (SC), another component of the self, and to identify neuroanatomical correlates, in prodromal to mild DLB.

Methods: Twenty patients with prodromal to mild DLB were selected to participate in this exploratory study along with 20 healthy control subjects matched in terms of age, gender, and level of education. The Twenty Statements Test (TST) was used to assess the SC. Behavioral performances were compared between LB patients and control subjects. Three-dimensional magnetic resonance images (MRI) were acquired for all participants and correlational analyses were performed using voxel-based morphometry (VBM) in whole brain and using a mask for the insula.

Results: The behavioral results on the TST showed significantly impaired performances in LB patients in comparison with control subjects (p < .0001). Correlational analyses using VBM revealed positive correlations between the TST and grey matter volume within insular cortex, right supplementary motor area, bilateral inferior temporal gyri, right inferior frontal gyrus, and left lingual gyrus, using a threshold of p = .001 uncorrected, including total intracranial volume (TIV), age, and MMSE as nuisance covariates. Additionally, correlational analysis using a mask for the insula revealed positive correlation with grey matter volume within bilateral insular cortex, using a threshold of p = .005.

Conclusions: The behavioral results confirm the existence of SC impairments in LB patients from the prodromal stage of the disease, compared to matched healthy controls. As we expected, VBM analyses revealed involvement of the insula, among that of other brain regions, already known to be involved in other self-components. While this study is exploratory, our findings provide important insights regarding the involvement of the insula within the self, confirming the insula as a core region of the self-networks, including for high-order self-representations such as the SC.

Keywords: Dementia with lewy bodies; Insula; Lewy bodies; Self; Self-concept; Semantic knowledge.

Fig. 1

VBM analyses for self-concept in the Lewy bodies group.Grey matter volumes within right insular cortex positively correlated with the total score on the TST questionnaire (self-concept), using a threshold of p = .001 uncorrected, including age, TIV and MMSE score as nuisance covariates, k = 50

Fig. 2

VBM analyses for self-concept in the Lewy bodies group.Grey matter volumes within right supplementary motor area positively correlated with the total score on the TST questionnaire, using a threshold of p = .001 uncorrected, including age, TIV, and MMSE score as nuisance covariates, k = 50

Fig. 3

VBM analyses for self-concept in the Lewy bodies group. Grey matter volumes within right insular cortex, right SMA, bilateral inferior temporal gyri, and left lingual gyrus positively correlated with the total score on the TST questionnaire, using a threshold of p = .001 uncorrected, including age, TIV, and MMSE score as nuisance covariates, k = 50

Fig. 4

VBM analyses for self-concept in Lewy bodies group, using a mask for the insula.Grey matter volumes within bilateral insular cortex, using a threshold of p = .005 uncorrected, including age, TIV, and MMSE score as nuisance covariates